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Ionic Liquids in Drug Delivery

Department of Chemistry, CICECO-Aveiro Institute of Materials, University of Aveiro, 3810-193 Aveiro, Portugal
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Academic Editor: Jose L. Arias
Encyclopedia 2021, 1(2), 324-339; https://doi.org/10.3390/encyclopedia1020027
Received: 23 February 2021 / Revised: 17 March 2021 / Accepted: 25 March 2021 / Published: 1 April 2021
(This article belongs to the Section Chemistry)
Ionic liquids (ILs) are molten salts composed of a large organic cation and an organic/inorganic anion. Due to their ionic character, most ILs present advantageous properties over conventional solvents, such as negligible volatility at atmospheric conditions and high thermal and chemical stabilities. The wide variety of IL anion–cation combinations allows these solvents to be designed to display a strong solvation ability for a myriad of active pharmaceutical ingredients (APIs) and (bio)polymers. Given these properties, ILs have been used as solvents and as formulation components in different areas of drug delivery, as well as novel liquid forms of APIs (API-ILs) applied in different stages of development of novel drug delivery systems. Furthermore, their combination with polymers and biopolymers has enabled the design of drug delivery systems for new therapeutic routes of administration. View Full-Text
Keywords: active pharmaceutical ingredients; drug delivery; formulations; ionic liquids; permeation enhancers; stimuli-responsive systems active pharmaceutical ingredients; drug delivery; formulations; ionic liquids; permeation enhancers; stimuli-responsive systems
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MDPI and ACS Style

Pedro, S.N.; Freire, C.S.R.; Silvestre, A.J.D.; Freire, M.G. Ionic Liquids in Drug Delivery. Encyclopedia 2021, 1, 324-339. https://doi.org/10.3390/encyclopedia1020027

AMA Style

Pedro SN, Freire CSR, Silvestre AJD, Freire MG. Ionic Liquids in Drug Delivery. Encyclopedia. 2021; 1(2):324-339. https://doi.org/10.3390/encyclopedia1020027

Chicago/Turabian Style

Pedro, Sónia N., Carmen S.R. Freire, Armando J.D. Silvestre, and Mara G. Freire. 2021. "Ionic Liquids in Drug Delivery" Encyclopedia 1, no. 2: 324-339. https://doi.org/10.3390/encyclopedia1020027

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