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Review

Harnessing Antiviral Peptides as Means for SARS-CoV-2 Control

by
Khatereh Zarkesh
1,
Mohsen Akbarian
2,
Lobat Tayebi
2,
Vladimir N. Uversky
3,
Alberto Rubio-Casillas
4,5,* and
Elrashdy M. Redwan
6,7,*
1
Department of Pharmaceutics, Faculty of Pharmacy, Hormozgan University of Medical Sciences, Bandar Abbas 79166-13885, Iran
2
School of Dentistry, Marquette University, Milwaukee, WI 53233, USA
3
Department of Molecular Medicine, USF Health Byrd Alzheimer’s Research Institute, Morsani College of Medicine, University of South Florida, Tampa, FL 33612, USA
4
Autlan Regional Hospital, Health Secretariat, Autlan 48900, Jalisco, Mexico
5
Biology Laboratory, Autlan Regional Preparatory School, University of Guadalajara, Autlan 48900, Jalisco, Mexico
6
Biological Sciences Department, Faculty of Science, King Abdulaziz University, Jeddah P.O. Box 80203, Saudi Arabia
7
Protein Research Department, Genetic Engineering and Biotechnology Research Institute (GEBRI), City of Scientific Research and Technological Applications (SRTA-City), New Borg El-Arab City, Alexandria P.O. Box 21934, Egypt
*
Authors to whom correspondence should be addressed.
COVID 2023, 3(7), 975-986; https://doi.org/10.3390/covid3070070
Submission received: 23 April 2023 / Revised: 25 June 2023 / Accepted: 27 June 2023 / Published: 29 June 2023
(This article belongs to the Topic Host Response against SARS-CoV-2 Infection: Implications for Diagnosis, Treatment and Vaccine Development)
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Abstract

Several times during the past two decades, epidemic viral diseases created global challenges. Although many solutions have been proposed to deal with this tight spot, it is still believed that public vaccination represents the most effective strategy to handle it. So far, various kinds of vaccines including protein subunits, virus-like particles, inactivated, live attenuated, viral vectors, RNA, and DNA vaccines have been used in the prevention of COVID-19. Among the various categories of vaccines, peptide vaccines have created a new hope for quick and trustworthy access due to the development of proteomics equipment. This review specifically focuses on vaccines and peptide therapies in severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). We consider here the efficacy and safety of subunit and synthetic peptides vaccine in clinical trial phases. Furthermore, monoclonal antibodies with the ability to suppress the development of SARS-CoV-2, those candidates that have entered into clinical trials until March 2023, were selected and evaluated.
Keywords: SARS-CoV-2; peptide vaccines; methodological processes; COVID-19 vaccination; monoclonal antibodies; clinical trials SARS-CoV-2; peptide vaccines; methodological processes; COVID-19 vaccination; monoclonal antibodies; clinical trials

Share and Cite

MDPI and ACS Style

Zarkesh, K.; Akbarian, M.; Tayebi, L.; Uversky, V.N.; Rubio-Casillas, A.; Redwan, E.M. Harnessing Antiviral Peptides as Means for SARS-CoV-2 Control. COVID 2023, 3, 975-986. https://doi.org/10.3390/covid3070070

AMA Style

Zarkesh K, Akbarian M, Tayebi L, Uversky VN, Rubio-Casillas A, Redwan EM. Harnessing Antiviral Peptides as Means for SARS-CoV-2 Control. COVID. 2023; 3(7):975-986. https://doi.org/10.3390/covid3070070

Chicago/Turabian Style

Zarkesh, Khatereh, Mohsen Akbarian, Lobat Tayebi, Vladimir N. Uversky, Alberto Rubio-Casillas, and Elrashdy M. Redwan. 2023. "Harnessing Antiviral Peptides as Means for SARS-CoV-2 Control" COVID 3, no. 7: 975-986. https://doi.org/10.3390/covid3070070

APA Style

Zarkesh, K., Akbarian, M., Tayebi, L., Uversky, V. N., Rubio-Casillas, A., & Redwan, E. M. (2023). Harnessing Antiviral Peptides as Means for SARS-CoV-2 Control. COVID, 3(7), 975-986. https://doi.org/10.3390/covid3070070

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