Next Article in Journal
Evolution of SARS-CoV-2 Strains in Senegal: From a Wild Wuhan Strain to the Omicron Variant
Previous Article in Journal
SARS-CoV-2 Intermittent Virulence as a Result of Natural Selection
 
 
Article

Clinical Outcomes and Severity of Acute Respiratory Distress Syndrome in 1154 COVID-19 Patients: An Experience Multicenter Retrospective Cohort Study

1
Research Center, Almoosa Specialist Hospital, Al-Ahsa 36342, Saudi Arabia
2
Research Center, College of Nursing, Princess Norah Bint Abdulrahman University, Riyadh 11564, Saudi Arabia
3
School of Nursing, Wollongong University, Wollongong, NSW 2522, Australia
4
Department of Nursing, Prince Sultan Military College, Dharan 34313, Saudi Arabia
5
Administration of Pharmaceutical Care, Al-Ahsa Health Cluster, Ministry of Health, Al-Ahsa 31982, Saudi Arabia
6
Research Office, King Abdullah International Medical Research Center, Riyadh 11481, Saudi Arabia
7
Department of Medicine, King Abdulaziz Medical City, Riyadh 11426, Saudi Arabia
8
College of Medicine and Health Sciences, Almanagil University, Almanagil 21116, Sudan
9
School of Medicine, RCSI Bahrain, Busaiteen 15503, Bahrain
10
Administration of Service Excellence, Al-Ahsa Health Cluster, Ministry of Health, Al-Ahsa 31982, Saudi Arabia
11
Phlebotomy Department, Al Iman General Hospital, Ministry of Health, Riyadh 12684, Saudi Arabia
12
Division of Hospital Internal Medicine, Mayo Clinic Health System, Mankato, MN 56001, USA
13
King Faisal Specialist Hospital, Riyadh 11564, Saudi Arabia
14
Department of General Surgery, Alomran General Hospital, Al-Ahsa 36355, Saudi Arabia
15
Basic Sciences Department, College of Applied Medical Sciences, King Saud Bin Abdulaziz University for Health Sciences, Al-Ahsa 31982, Saudi Arabia
16
Basic Sciences Department, College of Applied Medical Sciences, King Abdullah International Medical Research Center, Al-Ahsa 31982, Saudi Arabia
17
Department of Administration, College of Nursing, Imam Abdulrahman Bin Faisal University, Dammam 34221, Saudi Arabia
18
Infectious Disease Unit, Specialty Internal Medicine, Johns Hopkins Aramco Healthcare, Dhahran 34465, Saudi Arabia
19
Infectious Disease Division, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
20
Infectious Disease Division, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21218, USA
21
Department of Microbiology, The University of Haripur, Haripur 22610, Pakistan
22
Vice Deanship of Postgraduate Studies and Research, Prince Sultan Military College of Health Sciences, Dhahran 34313, Saudi Arabia
23
Clinical Laboratory Sciences, Prince Sultan Military College of Health Sciences, Dhahran 34313, Saudi Arabia
24
Vision Colleges of Medicine, Riyadh 11426, Saudi Arabia
25
College of Pharmacy, King Saud University, Riyadh 11426, Saudi Arabia
26
Maternity and Child Health Nursing Department, College of Nursing, Princess Nourah Bint Abdulrahman University, Riyadh 11564, Saudi Arabia
27
Molecular Diagnostic Laboratory, Johns Hopkins Aramco Healthcare, Dhahran 31311, Saudi Arabia
28
College of Medicine, Alfaisal University, Riyadh 11533, Saudi Arabia
29
Department of Public Health and Nutrition, The University of Haripur, Haripur 22610, Pakistan
*
Author to whom correspondence should be addressed.
Academic Editor: Luca Quartuccio
COVID 2022, 2(8), 1102-1115; https://doi.org/10.3390/covid2080081
Received: 9 June 2022 / Revised: 7 July 2022 / Accepted: 21 July 2022 / Published: 1 August 2022
Background: Acute Respiratory Distress Syndrome (ARDS) is caused by non-cardiogenic pulmonary edema and occurs in critically ill patients. It is one of the fatal complications observed among severe COVID-19 cases managed in intensive care units (ICU). Supportive lung-protective ventilation and prone positioning remain the mainstay interventions. Purpose: We describe the severity of ARDS, clinical outcomes, and management of ICU patients with laboratory-confirmed COVID-19 infection in multiple Saudi hospitals. Methods: A multicenter retrospective cohort study was conducted of critically ill patients who were admitted to the ICU with COVID-19 and developed ARDS. Results: During our study, 1154 patients experienced ARDS: 591 (51.2%) with severe, 415 (36.0%) with moderate, and 148 (12.8%) with mild ARDS. The mean sequential organ failure assessment (SOFA) score was significantly higher in severe ARDS with COVID-19 (6 ± 5, p = 0.006). Kaplan–Meier survival analysis showed COVID-19 patients with mild ARDS had a significantly higher survival rate compared to COVID-19 patients who experienced severe ARDS (p = 0.023). Conclusion: ARDS is a challenging condition complicating COVID-19 infection. It carries significant morbidity and results in elevated mortality. ARDS requires protective mechanical ventilation and other critical care supportive measures. The severity of ARDS is associated significantly with the rate of death among the patients. View Full-Text
Keywords: COVID-19; Acute Respiratory Distress Syndrome; ARDS; outcome; mortality; survival; risk factors COVID-19; Acute Respiratory Distress Syndrome; ARDS; outcome; mortality; survival; risk factors
Show Figures

Figure 1

MDPI and ACS Style

Al Mutair, A.; Alhumaid, S.; Layqah, L.; Shamou, J.; Ahmed, G.Y.; Chagla, H.; Alsalman, K.; Alnasser, F.M.; Thoyaja, K.; Alhuqbani, W.N.; Alghadeer, M.; Al Mohaini, M.; Almahmoud, S.; Al-Tawfiq, J.A.; Muhammad, J.; Al-Jamea, L.H.; Woodman, A.; Alsaleh, A.; Alsedrah, A.M.; Alharbi, H.F.; Saha, C.; Rabaan, A.A. Clinical Outcomes and Severity of Acute Respiratory Distress Syndrome in 1154 COVID-19 Patients: An Experience Multicenter Retrospective Cohort Study. COVID 2022, 2, 1102-1115. https://doi.org/10.3390/covid2080081

AMA Style

Al Mutair A, Alhumaid S, Layqah L, Shamou J, Ahmed GY, Chagla H, Alsalman K, Alnasser FM, Thoyaja K, Alhuqbani WN, Alghadeer M, Al Mohaini M, Almahmoud S, Al-Tawfiq JA, Muhammad J, Al-Jamea LH, Woodman A, Alsaleh A, Alsedrah AM, Alharbi HF, Saha C, Rabaan AA. Clinical Outcomes and Severity of Acute Respiratory Distress Syndrome in 1154 COVID-19 Patients: An Experience Multicenter Retrospective Cohort Study. COVID. 2022; 2(8):1102-1115. https://doi.org/10.3390/covid2080081

Chicago/Turabian Style

Al Mutair, Abbas, Saad Alhumaid, Laila Layqah, Jinan Shamou, Gasmelseed Y. Ahmed, Hiba Chagla, Khulud Alsalman, Fadhah Mohammed Alnasser, Koritala Thoyaja, Waad N. Alhuqbani, Mohammed Alghadeer, Mohammed Al Mohaini, Sana Almahmoud, Jaffar A. Al-Tawfiq, Javed Muhammad, Lamiaa H. Al-Jamea, Alexander Woodman, Ahmed Alsaleh, Abdulaziz M. Alsedrah, Hanan F. Alharbi, Chandni Saha, and Ali A. Rabaan. 2022. "Clinical Outcomes and Severity of Acute Respiratory Distress Syndrome in 1154 COVID-19 Patients: An Experience Multicenter Retrospective Cohort Study" COVID 2, no. 8: 1102-1115. https://doi.org/10.3390/covid2080081

Find Other Styles

Article Access Map by Country/Region

1
Back to TopTop