Evolution in the Definition of Follicular Lymphoma and Diffuse Large B-Cell Lymphoma: A Model for the Future of Personalized Medicine
Abstract
:1. Introduction
2. Evolving Spectrum of Follicular Lymphoma
3. Diffuse Large B-Cell Lymphoma NOS and Aggressive B-Cell Lymphomas
4. Pathology Provides a Roadmap for Disease Discovery and Treatment
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
- Jaffe, E.S.; Harris, N.L.; Swerdlow, S.H.; Ott, G.; Nathwani, B.N.; de Jong, D.; Yoshino, T.; Spagnolo, D.; Gascoyne, R.D. Follicular lymphoma. In WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues, 4th ed.; Swerdlow, S.H., Campo, E., Harris, N.L., Jaffe, E.S., Pileri, S.A., Stein, H., Thiele, J., Eds.; IARC Press: Lyon, France, 2017; pp. 266–277. [Google Scholar]
- Carbone, A.; Roulland, S.; Gloghini, A.; Younes, A.; von Keudell, G.; López-Guillermo, A.; Fitzgibbon, J. Follicular lymphoma. Nat. Rev. Dis. Primers 2019, 5, 83. (In English) [Google Scholar] [CrossRef]
- Swerdlow, S.H.; Campo, E.; Pileri, S.A.; Harris, N.L.; Stein, H.; Siebert, R.; Advani, R.; Ghielmini, M.; Salles, G.A.; Zelenetz, A.D.; et al. The 2016 revision of the World Health Organization classification of lymphoid neoplasms. Blood 2016, 127, 2375–2390. (In English) [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Gascoyne, R.D.; Chan, J.K.C.; Campo, E.; Rosenwald, A.; Jaffe, E.S.; Stein, H.; Chan, W.C.; Swerdlow, S.H. Diffuse large B-cell lymphoma, NOS. In WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues, 4th ed.; IARC, Ed.; IARC Press: Lyon, France, 2017; pp. 291–297. [Google Scholar]
- Mamessier, E.; Song, J.Y.; Eberle, F.C.; Pack, S.; Drevet, C.; Chetaille, B.; Abdullaev, Z.; Adelaide, J.; Birnbaum, D.; Chaffanet, M.; et al. Early lesions of follicular lymphoma: A genetic perspective. Haematologica 2014, 99, 481–488. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Schmidt, J.; Ramis-Zaldivar, J.E.; Bonzheim, I.; Steinhilber, J.; Muller, I.; Haake, A.; Yu, S.C.; Raffeld, M.; Fend, F.; Salaverria, I.; et al. CREBBP gene mutations are frequently detected in in situ follicular neoplasia. Blood 2018, 132, 2687–2690. (In English) [Google Scholar] [CrossRef] [Green Version]
- Jaffe, E.S.; Quintanilla-Martinez, L. t(14;18)-positive B cells: Is it seed or soil? Blood 2018, 132, 1631–1632. (In English) [Google Scholar] [CrossRef]
- Geyer, J.T.; Subramaniyam, S.; Jiang, Y.; Elemento, O.; Ferry, J.A.; de Leval, L.; Nakashima, M.O.; Liu, Y.C.; Martin, P.; Mathew, S.; et al. Lymphoblastic transformation of follicular lymphoma: A clinicopathologic and molecular analysis of 7 patients. Hum. Pathol. 2015, 46, 260–271. (In English) [Google Scholar] [CrossRef]
- Bhavsar, S.; Liu, Y.C.; Gibson, S.E.; Moore, E.M.; Swerdlow, S.H. Mutational Landscape of TdT+ Large B-cell Lymphomas Supports Their Distinction From B-lymphoblastic Neoplasms: A Multiparameter Study of a Rare and Aggressive Entity. Am. J. Surg. Pathol. 2022, 46, 71–82. (In English) [Google Scholar] [CrossRef]
- Feldman, A.L.; Arber, D.A.; Pittaluga, S.; Martinez, A.; Burke, J.S.; Raffeld, M.; Camos, M.; Warnke, R.; Jaffe, E.S. Clonally related follicular lymphomas and histiocytic/dendritic cell sarcomas: Evidence for transdifferentiation of the follicular lymphoma clone. Blood 2008, 111, 5433–5439. (In English) [Google Scholar] [CrossRef] [Green Version]
- Egan, C.; Lack, J.; Skarshaug, S.; Pham, T.A.; Abdullaev, Z.; Xi, L.; Pack, S.; Pittaluga, S.; Jaffe, E.S.; Raffeld, M. The mutational landscape of histiocytic sarcoma associated with lymphoid malignancy. Mod. Pathol. 2021, 34, 336–347. (In English) [Google Scholar] [CrossRef]
- Shanmugam, V.; Griffin, G.K.; Jacobsen, E.D.; Fletcher, C.D.M.; Sholl, L.M.; Hornick, J.L. Identification of diverse activating mutations of the RAS-MAPK pathway in histiocytic sarcoma. Mod. Pathol. 2019, 32, 830–843. (In English) [Google Scholar] [CrossRef]
- Nann, D.; Ramis-Zaldivar, J.E.; Müller, I.; Gonzalez-Farre, B.; Schmidt, J.; Egan, C.; Salmeron-Villalobos, J.; Clot, G.; Mattern, S.; Otto, F.; et al. Follicular lymphoma t(14;18)-negative is genetically a heterogeneous disease. Blood Adv. 2020, 4, 5652–5665. (In English) [Google Scholar] [CrossRef] [PubMed]
- Campo, E.; Jaffe, E.S.; Cook, J.R.; Quintanilla-Martinez, L.; Swerdlow, S.H.; Anderson, K.C.; Brousset, P.; Cerroni, L.; de Leval, L.; Dirnhofer, S.; et al. The International Consensus Classification of Mature Lymphoid Neoplasms: A Report from the Clinical Advisory Committee. Blood, 2022; in press. (In English). [Google Scholar] [CrossRef]
- Katzenberger, T.; Kalla, J.; Leich, E.; Stocklein, H.; Hartmann, E.; Barnickel, S.; Wessendorf, S.; Ott, M.M.; Muller-Hermelink, H.K.; Rosenwald, A.; et al. A distinctive subtype of t(14;18)-negative nodal follicular non-Hodgkin lymphoma characterized by a predominantly diffuse growth pattern and deletions in the chromosomal region 1p36. Blood 2009, 113, 1053–1061. Available online: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18978208 (accessed on 1 July 2022). (In English). [PubMed] [Green Version]
- Liu, Q.; Salaverria, I.; Pittaluga, S.; Jegalian, A.G.; Xi, L.; Siebert, R.; Raffeld, M.; Hewitt, S.M.; Jaffe, E.S. Follicular lymphomas in children and young adults: A comparison of the pediatric variant with usual follicular lymphoma. Am. J. Surg. Pathol. 2013, 37, 333–343. (In English) [Google Scholar] [CrossRef] [Green Version]
- Louissaint, A., Jr.; Schafernak, K.T.; Geyer, J.T.; Kovach, A.E.; Ghandi, M.; Gratzinger, D.; Roth, C.G.; Paxton, C.N.; Kim, S.; Namgyal, C.; et al. Pediatric-type nodal follicular lymphoma: A biologically distinct lymphoma with frequent MAPK pathway mutations. Blood 2016, 128, 1093–1100. (In English) [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Schmidt, J.; Ramis-Zaldivar, J.E.; Nadeu, F.; Gonzalez-Farre, B.; Navarro, A.; Egan, C.; Montes-Mojarro, I.A.; Marafioti, T.; Cabecadas, J.; van der Walt, J.; et al. Mutations of MAP2K1 are frequent in pediatric-type follicular lymphoma and result in ERK pathway activation. Blood 2017, 130, 323–327. (In English) [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Salmeron-Villalobos, J.; Egan, C.; Borgmann, V.; Müller, I.; Gonzalez-Farre, B.; Ramis-Zaldivar, J.E.; Nann, D.; Balagué, O.; Lopez-Guerra, M.; Colomer, D.; et al. PNMZL and PTFL: Morphological variants with a common molecular profile—A unifying hypothesis. Blood Adv. 2022; in press. (In English). [Google Scholar] [CrossRef]
- Louissaint, A., Jr.; Ackerman, A.M.; Dias-Santagata, D.; Ferry, J.A.; Hochberg, E.P.; Huang, M.S.; Iafrate, A.J.; Lara, D.O.; Pinkus, G.S.; Salaverria, I.; et al. Pediatric-type nodal follicular lymphoma: An indolent clonal proliferation in children and adults with high proliferation index and no BCL2 rearrangement. Blood 2012, 120, 2395–2404. (In English) [Google Scholar] [CrossRef] [Green Version]
- Ramis-Zaldivar, J.E.; Gonzalez-Farré, B.; Balagué, O.; Celis, V.; Nadeu, F.; Salmerón-Villalobos, J.; Andrés, M.; Martin-Guerrero, I.; Garrido-Pontnou, M.; Gaafar, A.; et al. Distinct molecular profile of IRF4-rearranged large B-cell lymphoma. Blood 2020, 135, 274–286. (In English) [Google Scholar] [CrossRef]
- Finn, L.S.; Viswanatha, D.S.; Belasco, J.B.; Snyder, H.; Huebner, D.; Sorbara, L.; Raffeld, M.; Jaffe, E.S.; Salhany, K.E. Primary follicular lymphoma of the testis in childhood. Cancer 1999, 85, 1626–1635. Available online: http://www.ncbi.nlm.nih.gov/pubmed/10193956 (accessed on 1 July 2022).
- Lones, M.A.; Raphael, M.; McCarthy, K.; Wotherspoon, A.; Terrier-Lacombe, M.J.; Ramsay, A.D.; Maclennan, K.; Cairo, M.S.; Gerrard, M.; Michon, J.; et al. Primary follicular lymphoma of the testis in children and adolescents. J. Pediatr. Hematol. Oncol. 2012, 34, 68–71. (In English) [Google Scholar] [CrossRef] [Green Version]
- Barasch, N.J.K.; Liu, Y.C.; Ho, J.; Bailey, N.; Aggarwal, N.; Cook, J.R.; Swerdlow, S.H. The molecular landscape and other distinctive features of primary cutaneous follicle center lymphoma. Hum. Pathol. 2020, 106, 93–105. (In English) [Google Scholar] [CrossRef]
- Gángó, A.; Bátai, B.; Varga, M.; Kapczár, D.; Papp, G.; Marschalkó, M.; Kuroli, E.; Schneider, T.; Csomor, J.; Matolcsy, A.; et al. Concomitant 1p36 deletion and TNFRSF14 mutations in primary cutaneous follicle center lymphoma frequently expressing high levels of EZH2 protein. Virchows Arch. 2018, 473, 453–462. (In English) [Google Scholar] [CrossRef] [PubMed]
- Lucioni, M.; Fraticelli, S.; Neri, G.; Feltri, M.; Ferrario, G.; Riboni, R.; Paulli, M. Primary Cutaneous B-Cell Lymphoma: An Update on Pathologic and Molecular Features. Hemato 2022, 3, 318–340. Available online: https://www.mdpi.com/2673-6357/3/2/23 (accessed on 1 July 2022).
- Hilton, L.K.; Tang, J.; Ben-Neriah, S.; Alcaide, M.; Jiang, A.; Grande, B.M.; Rushton, C.K.; Boyle, M.; Meissner, B.; Scott, D.W.; et al. The double-hit signature identifies double-hit diffuse large B-cell lymphoma with genetic events cryptic to FISH. Blood 2019, 134, 1528–1532. (In English) [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Salaverria, I.; Martin-Guerrero, I.; Wagener, R.; Kreuz, M.; Kohler, C.W.; Richter, J.; Pienkowska-Grela, B.; Adam, P.; Burkhardt, B.; Claviez, A.; et al. A recurrent 11q aberration pattern characterizes a subset of MYC-negative high-grade B-cell lymphomas resembling Burkitt lymphoma. Blood 2014, 123, 1187–1198. [Google Scholar] [CrossRef] [Green Version]
- Gonzalez-Farre, B.; Ramis-Zaldivar, J.E.; Salmeron-Villalobos, J.; Balagué, O.; Celis, V.; Verdu-Amoros, J.; Nadeu, F.; Sábado, C.; Ferrández, A.; Garrido, M.; et al. Burkitt-like lymphoma with 11q aberration: A germinal center-derived lymphoma genetically unrelated to Burkitt lymphoma. Haematologica 2019, 104, 1822–1829. (In English) [Google Scholar] [CrossRef]
- Wagener, R.; Seufert, J.; Raimondi, F.; Bens, S.; Kleinheinz, K.; Nagel, I.; Altmuller, J.; Thiele, H.; Hubschmann, D.; Kohler, C.W.; et al. The mutational landscape of Burkitt-like lymphoma with 11q aberration is distinct from that of Burkitt lymphoma. Blood 2019, 133, 962–966. (In English) [Google Scholar] [CrossRef] [Green Version]
- Moore, E.M.; Aggarwal, N.; Surti, U.; Swerdlow, S.H. Further Exploration of the Complexities of Large B-Cell Lymphomas with MYC Abnormalities and the Importance of a Blastoid Morphology. Am. J. Surg. Pathol. 2017, 41, 1155–1166. (In English) [Google Scholar] [CrossRef]
- Pillai, R.K.; Sathanoori, M.; Van Oss, S.B.; Swerdlow, S.H. Double-hit B-cell lymphomas with BCL6 and MYC translocations are aggressive, frequently extranodal lymphomas distinct from BCL2 double-hit B-cell lymphomas. Am. J. Surg. Pathol. 2013, 37, 323–332. (In English) [Google Scholar] [CrossRef]
- Chapuy, B.; Stewart, C.; Dunford, A.J.; Kim, J.; Kamburov, A.; Redd, R.A.; Lawrence, M.S.; Roemer, M.G.M.; Li, A.J.; Ziepert, M.; et al. Molecular subtypes of diffuse large B cell lymphoma are associated with distinct pathogenic mechanisms and outcomes. Nat. Med. 2018, 24, 679–690. (In English) [Google Scholar] [CrossRef]
- Schmitz, R.; Wright, G.W.; Huang, D.W.; Johnson, C.A.; Phelan, J.D.; Wang, J.Q.; Roulland, S.; Kasbekar, M.; Young, R.M.; Shaffer, A.L.; et al. Genetics and Pathogenesis of Diffuse Large B-Cell Lymphoma. N. Engl. J. Med. 2018, 378, 1396–1407. (In English) [Google Scholar] [CrossRef]
- Wright, G.W.; Huang, D.W.; Phelan, J.D.; Coulibaly, Z.A.; Roulland, S.; Young, R.M.; Wang, J.Q.; Schmitz, R.; Morin, R.D.; Tang, J.; et al. A Probabilistic Classification Tool for Genetic Subtypes of Diffuse Large B Cell Lymphoma with Therapeutic Implications. Cancer Cell 2020, 37, 551–568.e514. (In English) [Google Scholar] [CrossRef] [PubMed]
- Ennishi, D.; Hsi, E.D.; Steidl, C.; Scott, D.W. Toward a New Molecular Taxonomy of Diffuse Large B-cell Lymphoma. Cancer Discov. 2020, 10, 1267–1281. [Google Scholar] [CrossRef] [PubMed]
- Lacy, S.E.; Barrans, S.L.; Beer, P.A.; Painter, D.; Smith, A.G.; Roman, E.; Cooke, S.L.; Ruiz, C.; Glover, P.; Van Hoppe, S.J.L.; et al. Targeted sequencing in DLBCL, molecular subtypes, and outcomes: A Haematological Malignancy Research Network report. Blood 2020, 135, 1759–1771. (In English) [Google Scholar] [CrossRef] [PubMed]
- Sha, C.; Barrans, S.; Cucco, F.; Bentley, M.A.; Care, M.A.; Cummin, T.; Kennedy, H.; Thompson, J.S.; Uddin, R.; Worrillow, L.; et al. Molecular High-Grade B-Cell Lymphoma: Defining a Poor-Risk Group That Requires Different Approaches to Therapy. J. Clin. Oncol. 2019, 37, 202–212. (In English) [Google Scholar] [CrossRef]
- Jaffe, E.S.; Harris, N.L.; Stein, H.; Isaacson, P.G. Classification of lymphoid neoplasms: The microscope as a tool for disease discovery. Blood 2008, 112, 4384–4399. (In English) [Google Scholar] [CrossRef] [Green Version]
- Carbone, A. Classification of Tumors of the Hematopoietic and Lymphoid Tissues. Discovering Diseases—Defining Their Features. Hemato 2020, 1, 7–9. Available online: https://www.mdpi.com/2673-6357/1/1/4 (accessed on 1 July 2022).
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Jaffe, E.S.; Carbone, A. Evolution in the Definition of Follicular Lymphoma and Diffuse Large B-Cell Lymphoma: A Model for the Future of Personalized Medicine. Hemato 2022, 3, 466-474. https://doi.org/10.3390/hemato3030032
Jaffe ES, Carbone A. Evolution in the Definition of Follicular Lymphoma and Diffuse Large B-Cell Lymphoma: A Model for the Future of Personalized Medicine. Hemato. 2022; 3(3):466-474. https://doi.org/10.3390/hemato3030032
Chicago/Turabian StyleJaffe, Elaine S., and Antonino Carbone. 2022. "Evolution in the Definition of Follicular Lymphoma and Diffuse Large B-Cell Lymphoma: A Model for the Future of Personalized Medicine" Hemato 3, no. 3: 466-474. https://doi.org/10.3390/hemato3030032