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Article

Surface Microfabrication of Lactic Acid–Glycolic Acid Copolymers Using a Gas-Permeable Porous Mold

by
Mano Ando
1,
Yuna Hachikubo
1,
Sayaka Miura
1,
Rio Yamagishi
1,
Naoto Sugino
2,
Takao Kameda
2,
Yoshiyuki Yokoyama
3 and
Satoshi Takei
1,*
1
Department of Pharmaceutical Engineering, Toyrama Prefectural University, Imizu 939-0398, Toyama, Japan
2
Futuristic Technology Department, Sanko Gosei Ltd., Nanto 939-1852, Toyama, Japan
3
Toyama Industrial Technology Research and Development Center, Takaoka 933-0981, Toyama, Japan
*
Author to whom correspondence should be addressed.
Macromol 2024, 4(3), 544-555; https://doi.org/10.3390/macromol4030032
Submission received: 13 June 2024 / Revised: 29 July 2024 / Accepted: 1 August 2024 / Published: 5 August 2024
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Abstract

We attempted to perform surface microfabrication of the bioabsorbable material lactic acid–glycolic acid copolymer (LG-80) using a micro-imprint lithography technique with a gas-permeable porous mold at less than 5 °C. As a result, high-resolution surface micromachining with a height of 1.26 μm and a pitch of 2.97 μm was achieved using a convex sapphire mold with a height of 1.3 μm and a pitch of 3 μm. After processing, the LG-80 exhibited high water repellency, and FT-IR analysis of the surface showed no significant change in its chemical structure, confirming that the surface microfabrication was successful, while retaining the properties of the material. This demonstrated new possibilities for surface microfabrication technology for bioabsorbable materials, which are expected to be applied in the medical and life science fields in products such as surgical implants, tissue regeneration materials, and cell culture scaffold materials. In particular, the use of micro-imprint lithography enables low-cost and high-precision processing, which will be a major step toward the practical application of bioabsorbable materials.
Keywords: bioabsorbable materials; lactic acid–glycolic acid copolymer; surface micromachining; micro-imprint lithography technology; gas-permeable porous mold bioabsorbable materials; lactic acid–glycolic acid copolymer; surface micromachining; micro-imprint lithography technology; gas-permeable porous mold
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MDPI and ACS Style

Ando, M.; Hachikubo, Y.; Miura, S.; Yamagishi, R.; Sugino, N.; Kameda, T.; Yokoyama, Y.; Takei, S. Surface Microfabrication of Lactic Acid–Glycolic Acid Copolymers Using a Gas-Permeable Porous Mold. Macromol 2024, 4, 544-555. https://doi.org/10.3390/macromol4030032

AMA Style

Ando M, Hachikubo Y, Miura S, Yamagishi R, Sugino N, Kameda T, Yokoyama Y, Takei S. Surface Microfabrication of Lactic Acid–Glycolic Acid Copolymers Using a Gas-Permeable Porous Mold. Macromol. 2024; 4(3):544-555. https://doi.org/10.3390/macromol4030032

Chicago/Turabian Style

Ando, Mano, Yuna Hachikubo, Sayaka Miura, Rio Yamagishi, Naoto Sugino, Takao Kameda, Yoshiyuki Yokoyama, and Satoshi Takei. 2024. "Surface Microfabrication of Lactic Acid–Glycolic Acid Copolymers Using a Gas-Permeable Porous Mold" Macromol 4, no. 3: 544-555. https://doi.org/10.3390/macromol4030032

APA Style

Ando, M., Hachikubo, Y., Miura, S., Yamagishi, R., Sugino, N., Kameda, T., Yokoyama, Y., & Takei, S. (2024). Surface Microfabrication of Lactic Acid–Glycolic Acid Copolymers Using a Gas-Permeable Porous Mold. Macromol, 4(3), 544-555. https://doi.org/10.3390/macromol4030032

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