Immune Correlates of Non-Necrotic and Necrotic Granulomas in Pulmonary Tuberculosis: A Pilot Study
Abstract
:1. Introduction
2. Materials and Methods
2.1. Tissue Samples and Ethics
2.2. Chemicals and Antibodies
2.3. Single and Multiplex Immunohistochemistry
2.4. Imaging and Analysis
2.5. Statistical Analysis
3. Results
3.1. MDSCs Are Predominantly Present in Solid/Non-Necrotic Granulomas
3.2. MDSCs Elicit Their Immunosuppressive Function through an Induced Expression of NOS2, ARG1 and HIF-1α in Solid/Non-necrotic Granulomas
3.3. Solid/Non-Necrotic and Necrotic Granulomas Produce Similar Levels of IL-6 and IL-10
4. Discussion
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Conflicts of Interest
References
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Kumar, R.; Subbian, S. Immune Correlates of Non-Necrotic and Necrotic Granulomas in Pulmonary Tuberculosis: A Pilot Study. J. Respir. 2021, 1, 248-259. https://doi.org/10.3390/jor1040023
Kumar R, Subbian S. Immune Correlates of Non-Necrotic and Necrotic Granulomas in Pulmonary Tuberculosis: A Pilot Study. Journal of Respiration. 2021; 1(4):248-259. https://doi.org/10.3390/jor1040023
Chicago/Turabian StyleKumar, Ranjeet, and Selvakumar Subbian. 2021. "Immune Correlates of Non-Necrotic and Necrotic Granulomas in Pulmonary Tuberculosis: A Pilot Study" Journal of Respiration 1, no. 4: 248-259. https://doi.org/10.3390/jor1040023