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Volume 109
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Proceeding Paper

Development of a Nano- and Microfiber Mesh-Based Biosensor for the Rapid Quantification of Human C-Reactive Protein (CRP) †

by
Alexander Lloyd
1,*,
Willem Perold
1 and
Pieter Fourie
2
1
Department of Electrical and Electronic Engineering, Faculty of Engineering, Stellenbosch University, Stellenbosch 7600, South Africa
2
Innovation4life (PTY) Ltd., Stellenbosch 7600, South Africa
*
Author to whom correspondence should be addressed.
†
Presented at the Micro Manufacturing Convergence Conference, Stellenbosch, South Africa, 7–9 July 2024.
Eng. Proc. 2025, 109(1), 15; https://doi.org/10.3390/engproc2025109015
Published: 19 September 2025
(This article belongs to the Proceedings of Micro Manufacturing Convergence Conference)
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Abstract

Recent investigations into C-reactive protein (CRP) dynamics have shown that by evaluating the change in CRP level in a patient over time, it is possible to distinguish between bacterial and viral infections more accurately thereby guiding antimicrobial prescription practices. Consequently, a biosensor targeted towards CRP was developed using a nano- and microfiber mesh-based transducer. The produced transducers were functionalized with streptavidin, after which a biorecognition element, anti-CRP antibodies, could be bound to the sensor. Confirmation of the sensor production phases was obtained using fluorescence microscopy. The sensors were evaluated using Electrochemical Impedance Spectroscopy (EIS) and showed increasing changes in the impedance modulus corresponding to increasing concentrations of CRP in solution following a parabolic trend line.
Keywords: nanofiber; CRP; AMR; EIS; infection nanofiber; CRP; AMR; EIS; infection

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MDPI and ACS Style

Lloyd, A.; Perold, W.; Fourie, P. Development of a Nano- and Microfiber Mesh-Based Biosensor for the Rapid Quantification of Human C-Reactive Protein (CRP). Eng. Proc. 2025, 109, 15. https://doi.org/10.3390/engproc2025109015

AMA Style

Lloyd A, Perold W, Fourie P. Development of a Nano- and Microfiber Mesh-Based Biosensor for the Rapid Quantification of Human C-Reactive Protein (CRP). Engineering Proceedings. 2025; 109(1):15. https://doi.org/10.3390/engproc2025109015

Chicago/Turabian Style

Lloyd, Alexander, Willem Perold, and Pieter Fourie. 2025. "Development of a Nano- and Microfiber Mesh-Based Biosensor for the Rapid Quantification of Human C-Reactive Protein (CRP)" Engineering Proceedings 109, no. 1: 15. https://doi.org/10.3390/engproc2025109015

APA Style

Lloyd, A., Perold, W., & Fourie, P. (2025). Development of a Nano- and Microfiber Mesh-Based Biosensor for the Rapid Quantification of Human C-Reactive Protein (CRP). Engineering Proceedings, 109(1), 15. https://doi.org/10.3390/engproc2025109015

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