Conjugated Polymeric Liposomes: A Hybrid Carrier for Contemporary Drug Delivery †
Abstract
:1. Introduction
2. Conventional Liposomes
- Active targeting—in active targeting, to increase contact with a targeted cellular membrane, certain targeting ligands are linked to the liposome surface [9]. Through receptor-mediated endocytosis (RME), often referred to as active drug targeting, those ligands bind to specific receptors on the surface of cells and encourage the internalisation of therapeutic compounds that operate on cellular organelles, such as mitochondria, microtubules, the nucleus, etc. [10].
- Passive Targeting—the primary reason liposomes are able to passively target tumour tissues is due to the differing pore diameters of tumour vascular endothelium as compared to the ‘tightened’ structures present within healthy capillaries. An optimal targeting aim would be attained if liposomes were prepared with a size that allows them to extravasate in tumour tissues, simultaneously preventing the carriers from exiting the capillaries in healthy tissue [11].
3. Conjugated Polymeric Liposomes
3.1. “Grafted” Polymeric Liposomes
3.1.1. PEG (Polyethylene Glycol) Grafted Liposomes
3.1.2. Zwitter Ion Grafted Liposome
3.2. “Coated” Polymeric Liposomes
4. Application of Conjugated Polymeric Liposomes
4.1. Stimuli Responsive
4.2. pH Sensitive
4.3. Thermosensitive
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Advantages | |
---|---|
Enhanced solubility | |
Conjugated Polymeric Liposomes | Prolong circulation time |
Improving immunological response | |
Surpassing biological barriers | |
Controlled release of drugs | |
Greater payload |
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Patil, J.; Girase, T.; Patil, S.G.; Suryawanshi, H.; Patil, S.A. Conjugated Polymeric Liposomes: A Hybrid Carrier for Contemporary Drug Delivery. Chem. Proc. 2022, 12, 12. https://doi.org/10.3390/ecsoc-26-13640
Patil J, Girase T, Patil SG, Suryawanshi H, Patil SA. Conjugated Polymeric Liposomes: A Hybrid Carrier for Contemporary Drug Delivery. Chemistry Proceedings. 2022; 12(1):12. https://doi.org/10.3390/ecsoc-26-13640
Chicago/Turabian StylePatil, Javesh, Tejasweeni Girase, Sulbha G. Patil, Hemant Suryawanshi, and Sunila A. Patil. 2022. "Conjugated Polymeric Liposomes: A Hybrid Carrier for Contemporary Drug Delivery" Chemistry Proceedings 12, no. 1: 12. https://doi.org/10.3390/ecsoc-26-13640