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Livers, Volume 2, Issue 1

2022 March - 5 articles

Cover Story: Non-alcoholic fatty liver disease (NAFLD) is a challenging disease that is caused by multiple factors, which may partly explain why it remains an orphan of adequate therapies. This review highlights the interaction between oxidative stress (OS) and disturbed lipid metabolism. Several reactive oxygen species generators contribute to the lipotoxic hepatic (and extrahepatic) damage caused by fatty acids and a great variety of their biologically active metabolites in a “multiple parallel-hit model”. This leads to hepatic inflammation and fibrogenesis. The alterations also affect metabolism-related organelles, causing lipid peroxidation and mitochondrial dysfunction. In turn, all processes (including the physiological antioxidant counter-regulation) are under the influence of individual genetic factors. View this paper
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Articles (5)

  • Commentary
  • Open Access
1 Citations
9,069 Views
7 Pages
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Anti-Inflammatory Dietary Approach to Prevent the Development and Progression of Non-Alcoholic Fatty Liver Diseases

  • Dorothea Portius
Livers2022, 2(1), 78-84;https://doi.org/10.3390/livers2010005

2 March 2022

Non-alcoholic fatty liver disease (NAFLD) is an increasing health problem worldwide and is associated with insulin resistance, increased visceral fat mass, and cardiovascular problems. Lifestyle factors such as sedentary lifestyle, chronic stress, ob...

Full Article
  • Review
  • Open Access
87 Citations
21,397 Views
47 Pages
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Oxidative Stress in Non-Alcoholic Fatty Liver Disease

  • Carlo Smirne,
  • Eleonora Croce,
  • Davide Di Benedetto,
  • Vincenzo Cantaluppi,
  • Cristoforo Comi,
  • Pier Paolo Sainaghi,
  • Rosalba Minisini,
  • Elena Grossini and
  • Mario Pirisi
Livers2022, 2(1), 30-76;https://doi.org/10.3390/livers2010003

1 February 2022

Non-alcoholic fatty liver disease (NAFLD) is a challenging disease caused by multiple factors, which may partly explain why it still remains an orphan of adequate therapies. This review highlights the interaction between oxidative stress (OS) and dis...

Full Article
  • Review
  • Open Access
7 Citations
7,298 Views
15 Pages
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TAM Receptors in the Pathophysiology of Liver Disease

  • Emilio Flint,
  • Evangelos Triantafyllou and
  • Christine Bernsmeier
Livers2022, 2(1), 15-29;https://doi.org/10.3390/livers2010002

15 January 2022

TAM receptors (Tyro3, Axl and MerTK) are a family of tyrosine kinase receptors that are expressed in a variety of cell populations, including liver parenchymal and non-parenchymal cells. These receptors are vital for immune homeostasis, as they regul...

Full Article
  • Review
  • Open Access
3,765 Views
14 Pages
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Cellular and Molecular Mechanisms Underlying Scope and Limitation of Ongoing and Innovative Therapies for Treating Chronic Hepatitis B

  • Sheikh Mohammad Fazle Akbar,
  • Mamun Al Mahtab,
  • Osamu Yoshida and
  • Yoichi Hiasa
Livers2022, 2(1), 1-14;https://doi.org/10.3390/livers2010001

6 January 2022

Millions of people of the world suffer from chronic hepatitis B (CHB), a pathological entity in which the patients are chronically infected with hepatitis B virus (HBV) and express hepatitis B surface antigen (HBsAg) and HBV DNA, as well as evidence...

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