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Using Chitosan or Chitosan Derivatives in Cancer Therapy

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Department of Pharmacology and Toxicology, University of Otago, Dunedin 9016, New Zealand
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Department of Biochemistry, Primeasia University, Banani, Dhaka 1213, Bangladesh
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Department of Biochemistry and Molecular Biology, Jahangirnagar University, Savar, Dhaka 1342, Bangladesh
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Department of Biochemistry and Molecular Biology, University of Dhaka, Dhaka 1000, Bangladesh
*
Authors to whom correspondence should be addressed.
Academic Editor: Cédric Delattre
Polysaccharides 2021, 2(4), 795-816; https://doi.org/10.3390/polysaccharides2040048
Received: 7 August 2021 / Revised: 30 September 2021 / Accepted: 6 October 2021 / Published: 13 October 2021
(This article belongs to the Collection Current Opinion in Polysaccharides)
Cancer is one of the major causes of death worldwide. Chemotherapeutic drugs have become a popular choice as anticancer agents. Despite the therapeutic benefits of chemotherapeutic drugs, patients often experience side effects and drug resistance. Biopolymers could be used to overcome some of the limitations of chemotherapeutic drugs, as well as be used either as anticancer agents or drug delivery vehicles. Chitosan is a biocompatible polymer derived from chitin. Chitosan, chitosan derivatives, or chitosan nanoparticles have shown their promise as an anticancer agent. Additionally, functionally modified chitosan can be used to deliver nucleic acids, chemotherapeutic drugs, and anticancer agents. More importantly, chitosan-based drug delivery systems improved the efficacy, potency, cytotoxicity, or biocompatibility of these anticancer agents. In this review, we will investigate the properties of chitosan and chemically tuned chitosan derivatives, and their application in cancer therapy. View Full-Text
Keywords: chitosan; chitosan derivatives; anticancer activities; gene and drug delivery; immunotherapy chitosan; chitosan derivatives; anticancer activities; gene and drug delivery; immunotherapy
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MDPI and ACS Style

Shakil, M.S.; Mahmud, K.M.; Sayem, M.; Niloy, M.S.; Halder, S.K.; Hossen, M.S.; Uddin, M.F.; Hasan, M.A. Using Chitosan or Chitosan Derivatives in Cancer Therapy. Polysaccharides 2021, 2, 795-816. https://doi.org/10.3390/polysaccharides2040048

AMA Style

Shakil MS, Mahmud KM, Sayem M, Niloy MS, Halder SK, Hossen MS, Uddin MF, Hasan MA. Using Chitosan or Chitosan Derivatives in Cancer Therapy. Polysaccharides. 2021; 2(4):795-816. https://doi.org/10.3390/polysaccharides2040048

Chicago/Turabian Style

Shakil, Md S., Kazi M. Mahmud, Mohammad Sayem, Mahruba S. Niloy, Sajal K. Halder, Md. S. Hossen, Md. F. Uddin, and Md. A. Hasan 2021. "Using Chitosan or Chitosan Derivatives in Cancer Therapy" Polysaccharides 2, no. 4: 795-816. https://doi.org/10.3390/polysaccharides2040048

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