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Osteology, Volume 1, Issue 4

December 2021 - 6 articles

Cover Story: We present data from a proof-of-principle longitudinal study employing two opioid administration routes (subcutaneous injection, transdermal patch) to evaluate the efficacy of drug delivery modality during chronic opioid exposure in a rabbit model system. Skeletally mature male New Zealand White rabbits were divided into three groups: morphine sulphate, fentanyl, and control. Experimental treatments were conducted for eight weeks. Preparation of the skin at the fentanyl patch site and subsequent patch removal presented experimental difficulties, including consistent erythema and acute stress in fentanyl animals. Thus, transdermal fentanyl patches are an ineffective delivery system for longitudinal analgesic experimental projects employing a rabbit model system. View this paper

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Articles (6)

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Article

2 Citations

2,686 Views

9 Pages

Linear-Chain Nanostructured Carbon with a Silver Film Plated on Metal Components Has a Promising Effect for the Treatment of Periprosthetic Joint Infection

Leonid I. Maliuchenko,
Nikolay S. Nikolaev,
Nadezhda N. Pchelova,
Dmitry Nikolaevich Efimov,
Elena V. Preobrazhenskaia and
Vladimir U. Emelianov

Osteology2021, 1(4), 238-246;https://doi.org/10.3390/osteology1040022

8 December 2021

Background: Due to the aging of the world population, the number of joint diseases, along with the number of arthroplasties, has increased, simultaneously increasing the amount of complications, including periprosthetic joint infection (PPI). In this...

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Article

1 Citations

6,014 Views

13 Pages

Rabbits (Oryctolagus cuniculus) as a Model System for Longitudinal Experimental Opioid Treatments: Implications for Orthopedic and Biomedical Research

Janna M. Andronowski,
Adam J. Schuller,
Mary E. Cole,
Abigail R. LaMarca,
Reed A. Davis and
Gina R. Tubo

Osteology2021, 1(4), 225-237;https://doi.org/10.3390/osteology1040021

18 November 2021

Due to the high prevalence of opioid prescription following orthopedic procedures, there is a growing need to establish an animal model system to evaluate the effects of opioids on bone remodeling. Rabbits have been employed as model organisms in ort...

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Review

14 Citations

6,272 Views

16 Pages

Immunomodulatory Actions of Mesenchymal Stromal Cells (MSCs) in Osteoarthritis of the Knee

Gangireddi Suresh Babu,
Yelisetty Badrish,
Vinit M Oswal,
Naveen Jeyaraman,
Gollahalli Shivashankar Prajwal,
Madhan Jeyaraman,
Sathish Muthu and
Manish Khanna

Osteology2021, 1(4), 209-224;https://doi.org/10.3390/osteology1040020

17 November 2021

Cellular therapy offers regeneration which curbs osteoarthritis of the knee. Among cellular therapies, mesenchymal stromal cells (MSCs) are readily isolated from various sources as culture expanded and unexpanded cellular population which are used as...

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Review

5 Citations

5,866 Views

12 Pages

Patellar Instability in Pediatric Patients: Review of the Literature

Filippo Familiari,
Riza Mert Cetik and
Gazi Huri

Osteology2021, 1(4), 197-208;https://doi.org/10.3390/osteology1040019

24 October 2021

Patellar instability is a common pathology of the knee in pediatric patients. The management of this condition can be a challenge for the orthopedic surgeon, and a comprehensive understanding of the anatomy and biomechanics of the structures around t...

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Article

7 Citations

6,266 Views

10 Pages

Prevalence and Patterns of Risk of Osteoporosis in Bangladeshi Adult Population: An Analysis of Calcaneus Quantitative Ultrasound Measurements

Mohammad Ali,
Zakir Uddin and
Ahmed Hossain

Osteology2021, 1(4), 187-196;https://doi.org/10.3390/osteology1040018

3 October 2021

(1) Objectives: A little is known about the prevalence of the “risk of osteoporosis (RO)” and the factors associated with RO among Bangladeshi adults. Using a cost-effective testing tool, this study aimed to investigate the prevalence of RO and find...

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Review

6 Citations

15,340 Views

12 Pages

An Overview of Achilles Tendinopathy Management

Fabio Santacaterina,
Sandra Miccinilli,
Federica Bressi,
Silvia Sterzi and
Marco Bravi

Osteology2021, 1(4), 175-186;https://doi.org/10.3390/osteology1040017

29 September 2021

Background: Persistent tendon pain and swelling related to mechanical loading are the main signs of Achilles tendinopathy (AT). This condition is one of the most common tendinopathies of the lower limb affecting mainly athletes involved in running an...

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