A Sustainable Improvement of ω-Bromoalkylphosphonates Synthesis to Access Novel KuQuinones
Abstract
:1. Introduction
2. Materials and Methods
2.1. Optimized Procedure for the Synthesis of Diethyl ω-Bromoalkylphosphonate
2.2. General Procedure for the Synthesis of 1-[n-(Diethyl phosphonyl) alkyl]KuQuinone
2.3. Hydrolysis of Diethyl Phosphonate KuQuinone Derivatives
3. Results and Discussion
4. Conclusions
Supplementary Materials
Author Contributions
Funding
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Entry | Br(CH2)nBr | Reaction Time | Isolated Yield (%) |
---|---|---|---|
1 | n = 4 | 12 h | - |
2 a | n = 4 | 12 h | - |
3 b | n = 4 | 5 min | - |
4 a,c | n = 6 | 90 min | 5 |
5 a,d | n = 6 | 3 h | 40 |
6 a,d | n = 5 | 3 h | 40 |
7 a,d | n = 4 | 3 h | 20 e |
Reagent | Product | Yield (%) |
---|---|---|
1 | 4 | 11 |
2 | 5 | 10 |
3 | 6 | 7 |
Reagent | Product | Yield (%) |
---|---|---|
4 | 7 | 100 |
5 | 8 | 95 |
6 | 9 | 97 |
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Forchetta, M.; Conte, V.; Fiorani, G.; Galloni, P.; Sabuzi, F. A Sustainable Improvement of ω-Bromoalkylphosphonates Synthesis to Access Novel KuQuinones. Organics 2021, 2, 107-117. https://doi.org/10.3390/org2020010
Forchetta M, Conte V, Fiorani G, Galloni P, Sabuzi F. A Sustainable Improvement of ω-Bromoalkylphosphonates Synthesis to Access Novel KuQuinones. Organics. 2021; 2(2):107-117. https://doi.org/10.3390/org2020010
Chicago/Turabian StyleForchetta, Mattia, Valeria Conte, Giulia Fiorani, Pierluca Galloni, and Federica Sabuzi. 2021. "A Sustainable Improvement of ω-Bromoalkylphosphonates Synthesis to Access Novel KuQuinones" Organics 2, no. 2: 107-117. https://doi.org/10.3390/org2020010