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Open AccessArticle

Effect of High-Dose Intravenous Vitamin C on Postpartum Oxidative Stress in Severe Preeclampsia

1
Department of Perinatology, Division of Obstetrics and Gynecology, University Medical Center Ljubljana, Slajmerjeva 4, 1000 Ljubljana, Slovenia
2
Institute of Clinical Chemistry and Biochemistry, University Medical Center Ljubljana, Njegoseva 4, 1000 Ljubljana, Slovenia
3
Faculty of Medicine, University of Ljubljana, Vrazov trg 2, 1000 Ljubljana, Slovenia
*
Author to whom correspondence should be addressed.
Reprod. Med. 2020, 1(2), 122-131; https://doi.org/10.3390/reprodmed1020009
Received: 9 July 2020 / Revised: 18 August 2020 / Accepted: 26 August 2020 / Published: 28 August 2020
(This article belongs to the Special Issue Preeclampsia: Pathogenesis, Diagnosis and Treatment)
Purpose: To determine whether high-dose intravenous vitamin C reduces oxidative stress in patients with severe preeclampsia in the first days postpartum. Methods: Biomarkers of oxidative stress were assessed as secondary outcomes of a single-center, randomized, placebo-controlled trial. Thirty-four patients with singleton pregnancies complicated by severe features of preeclampsia were randomized into two groups: intravenous vitamin C (1.5 g/6 h) (n = 17) or placebo (n = 17). Urinary concentrations of dityrosine, 8-hydroxy-2-deoxyguanosine (8-OHdg), 8-isoprostane, and N epsilon-(hexanoyl) lysine (HEL) were measured at days one and three after delivery and normalized for urinary creatinine in 22 of patients included (12 in vitamin C and 10 in placebo group). The Mann–Whitney U-test was used to compare values of oxidative stress biomarkers at days one and three after delivery in vitamin C vs. placebo groups (p ≤ 0.05 significant). Results: Dityrosine and 8-OHdg values did not differ significantly between the two study groups at day one after delivery (p = 0.23 and p = 0.77, respectively), but were significantly lower in the vitamin C group compared to the placebo group at day three after delivery (p = 0.04 and p = 0.03, respectively). Values of 8-isoprostane and HEL did not differ significantly between the two study groups at day one (p = 0.41 and p = 0.42, respectively), as well as at day three, after delivery (p = 0.25 and p = 0.24, respectively). Conclusion: High-dose intravenous vitamin C treatments in patients with severe preeclampsia reduced urinary levels of dityrosine and 8-OHdg (markers of protein and DNA oxidative damage, respectively) on day three after delivery. Vitamin C treatment had no significant effect on lipid peroxidation biomarkers, i.e., 8-isoprostane and HEL. View Full-Text
Keywords: ascorbic acid; oxidative stress; preeclampsia; vitamin C ascorbic acid; oxidative stress; preeclampsia; vitamin C
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MDPI and ACS Style

Korenc, M.; Osredkar, J.; Gersak, K.; Kumer, K.; Fabjan, T.; Sterpin, S.; Lucovnik, M. Effect of High-Dose Intravenous Vitamin C on Postpartum Oxidative Stress in Severe Preeclampsia. Reprod. Med. 2020, 1, 122-131. https://doi.org/10.3390/reprodmed1020009

AMA Style

Korenc M, Osredkar J, Gersak K, Kumer K, Fabjan T, Sterpin S, Lucovnik M. Effect of High-Dose Intravenous Vitamin C on Postpartum Oxidative Stress in Severe Preeclampsia. Reproductive Medicine. 2020; 1(2):122-131. https://doi.org/10.3390/reprodmed1020009

Chicago/Turabian Style

Korenc, Monika; Osredkar, Joško; Gersak, Ksenija; Kumer, Kristina; Fabjan, Teja; Sterpin, Sasa; Lucovnik, Miha. 2020. "Effect of High-Dose Intravenous Vitamin C on Postpartum Oxidative Stress in Severe Preeclampsia" Reprod. Med. 1, no. 2: 122-131. https://doi.org/10.3390/reprodmed1020009

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