Effect of High-Dose Intravenous Vitamin C on Postpartum Oxidative Stress in Severe Preeclampsia
Abstract
:1. Introduction
2. Methods
2.1. Oxidative Stress Biomarker Measurements
2.2. Statistical Analysis
3. Results
4. Discussion
Author Contributions
Funding
Conflicts of Interest
References
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Characteristic | Vitamin C (n = 12) | Placebo (n = 10) | p-Value |
---|---|---|---|
Maternal age (years) | 30 (22–41) | 30 (23–40) | 0.97 |
Pre-pregnancy BMI (kg/m2) | 23 (17–35) | 26 (18–41) | 0.23 |
BMI at delivery (kg/m2) | 29 (22–56) | 31 (20–49) | 0.69 |
Nulliparity | 10 (83%) | 7 (70%) | 0.28 |
Gestational age (weeks) | 33 (24–38) | 33 (26–39) | 0.38 |
Caesarean delivery | 9 (75%) | 9 (90%) | 0.69 |
Neonatal birth weight (g) | 1465 (490–3110) | 1820 (630–3870) | 0.33 |
SGA | 8 (67%) | 4 (40%) | 0.15 |
Systolic blood pressure ≥160 mm Hg at inclusion | 12 (100%) | 10 (100%) | / |
Diastolic blood pressure ≥110 mm Hg at inclusion | 12 (100%) | 10 (100%) | / |
Neurological symptoms | 3 (25%) | 4 (40%) | 0.21 |
Serum creatinine >97 µmol/L | 1 (8%) | 0 (0%) | 0.33 |
Elevated liver enzymes and/or pain in the right upper or middle upper abdomen | 8 (67%) | 3 (30%) | 0.09 |
Thrombocytopenia | 3 (25%) | 2 (20%) | 0.78 |
Urine output at inclusion (mL/kg/h) | 0.62 (0.40–1.17) | 0.52 (0.27–1.33) | 0.42 |
Serum creatinine at inclusion (µmol/L) | 59 (48–133) | 55 (43–67) | 0.35 |
sFlt-1/PlGF | 268 (152–2324) | 399 (111–998) | 0.12 |
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Korenc, M.; Osredkar, J.; Gersak, K.; Kumer, K.; Fabjan, T.; Sterpin, S.; Lucovnik, M. Effect of High-Dose Intravenous Vitamin C on Postpartum Oxidative Stress in Severe Preeclampsia. Reprod. Med. 2020, 1, 122-131. https://doi.org/10.3390/reprodmed1020009
Korenc M, Osredkar J, Gersak K, Kumer K, Fabjan T, Sterpin S, Lucovnik M. Effect of High-Dose Intravenous Vitamin C on Postpartum Oxidative Stress in Severe Preeclampsia. Reproductive Medicine. 2020; 1(2):122-131. https://doi.org/10.3390/reprodmed1020009
Chicago/Turabian StyleKorenc, Monika, Joško Osredkar, Ksenija Gersak, Kristina Kumer, Teja Fabjan, Sasa Sterpin, and Miha Lucovnik. 2020. "Effect of High-Dose Intravenous Vitamin C on Postpartum Oxidative Stress in Severe Preeclampsia" Reproductive Medicine 1, no. 2: 122-131. https://doi.org/10.3390/reprodmed1020009