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Review

Theranostic Applications of Nanoparticle-Mediated Photoactivated Therapies

1
Institute of Molecular Medicine, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China
2
Institute of Biology and Biomedicine, Lobachevsky State University of Nizhny Novgorod, 603950 Nizhny Novgorod, Russia
3
Center of Biomedical Engineering, Sechenov University, 119991 Moscow, Russia
4
MQ Photonics Centre, Faculty of Science and Engineering, Macquarie University, Sydney, NSW 2109, Australia
5
Department of Chemistry, University of Delhi, Delhi 110007, India
*
Author to whom correspondence should be addressed.
Academic Editor: Fedor Zhuravlev
J. Nanotheranostics 2021, 2(3), 131-156; https://doi.org/10.3390/jnt2030009
Received: 10 May 2021 / Revised: 23 July 2021 / Accepted: 26 July 2021 / Published: 3 August 2021
(This article belongs to the Special Issue Recent Advancements in Nanoparticle Based Imaging and Therapy)
Nanoparticle-mediated light-activated therapies, such as photodynamic therapy and photothermal therapy, are earnestly being viewed as efficient interventional strategies against several cancer types. Theranostics is a key hallmark of cancer nanomedicine since it allows diagnosis and therapy of both primary and metastatic cancer using a single nanoprobe. Advanced in vivo diagnostic imaging using theranostic nanoparticles not only provides precise information about the location of tumor/s but also outlines the narrow time window corresponding to the maximum tumor-specific drug accumulation. Such information plays a critical role in guiding light-activated therapies with high spatio-temporal accuracy. Furthermore, theranostics facilitates monitoring the progression of therapy in real time. Herein, we provide a general review of the application of theranostic nanoparticles for in vivo image-guided light-activated therapy in cancer. The imaging modalities considered here include fluorescence imaging, photoacoustic imaging, thermal imaging, magnetic resonance imaging, X-ray computed tomography, positron emission tomography, and single-photon emission computed tomography. The review concludes with a brief discussion about the broad scope of theranostic light-activated nanomedicine. View Full-Text
Keywords: theranostic nanoparticles; image-guided therapy; real-time therapy monitoring; photodynamic therapy; photothermal therapy theranostic nanoparticles; image-guided therapy; real-time therapy monitoring; photodynamic therapy; photothermal therapy
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MDPI and ACS Style

Sharma, S.; Zvyagin, A.V.; Roy, I. Theranostic Applications of Nanoparticle-Mediated Photoactivated Therapies. J. Nanotheranostics 2021, 2, 131-156. https://doi.org/10.3390/jnt2030009

AMA Style

Sharma S, Zvyagin AV, Roy I. Theranostic Applications of Nanoparticle-Mediated Photoactivated Therapies. Journal of Nanotheranostics. 2021; 2(3):131-156. https://doi.org/10.3390/jnt2030009

Chicago/Turabian Style

Sharma, Shalini, Andrei V. Zvyagin, and Indrajit Roy. 2021. "Theranostic Applications of Nanoparticle-Mediated Photoactivated Therapies" Journal of Nanotheranostics 2, no. 3: 131-156. https://doi.org/10.3390/jnt2030009

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