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Theranostic Applications of Nanoparticle-Mediated Photoactivated Therapies

Institute of Molecular Medicine, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China
Institute of Biology and Biomedicine, Lobachevsky State University of Nizhny Novgorod, 603950 Nizhny Novgorod, Russia
Center of Biomedical Engineering, Sechenov University, 119991 Moscow, Russia
MQ Photonics Centre, Faculty of Science and Engineering, Macquarie University, Sydney, NSW 2109, Australia
Department of Chemistry, University of Delhi, Delhi 110007, India
Author to whom correspondence should be addressed.
Academic Editor: Fedor Zhuravlev
J. Nanotheranostics 2021, 2(3), 131-156;
Received: 10 May 2021 / Revised: 23 July 2021 / Accepted: 26 July 2021 / Published: 3 August 2021
(This article belongs to the Special Issue Recent Advancements in Nanoparticle Based Imaging and Therapy)
Nanoparticle-mediated light-activated therapies, such as photodynamic therapy and photothermal therapy, are earnestly being viewed as efficient interventional strategies against several cancer types. Theranostics is a key hallmark of cancer nanomedicine since it allows diagnosis and therapy of both primary and metastatic cancer using a single nanoprobe. Advanced in vivo diagnostic imaging using theranostic nanoparticles not only provides precise information about the location of tumor/s but also outlines the narrow time window corresponding to the maximum tumor-specific drug accumulation. Such information plays a critical role in guiding light-activated therapies with high spatio-temporal accuracy. Furthermore, theranostics facilitates monitoring the progression of therapy in real time. Herein, we provide a general review of the application of theranostic nanoparticles for in vivo image-guided light-activated therapy in cancer. The imaging modalities considered here include fluorescence imaging, photoacoustic imaging, thermal imaging, magnetic resonance imaging, X-ray computed tomography, positron emission tomography, and single-photon emission computed tomography. The review concludes with a brief discussion about the broad scope of theranostic light-activated nanomedicine. View Full-Text
Keywords: theranostic nanoparticles; image-guided therapy; real-time therapy monitoring; photodynamic therapy; photothermal therapy theranostic nanoparticles; image-guided therapy; real-time therapy monitoring; photodynamic therapy; photothermal therapy
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MDPI and ACS Style

Sharma, S.; Zvyagin, A.V.; Roy, I. Theranostic Applications of Nanoparticle-Mediated Photoactivated Therapies. J. Nanotheranostics 2021, 2, 131-156.

AMA Style

Sharma S, Zvyagin AV, Roy I. Theranostic Applications of Nanoparticle-Mediated Photoactivated Therapies. Journal of Nanotheranostics. 2021; 2(3):131-156.

Chicago/Turabian Style

Sharma, Shalini, Andrei V. Zvyagin, and Indrajit Roy. 2021. "Theranostic Applications of Nanoparticle-Mediated Photoactivated Therapies" Journal of Nanotheranostics 2, no. 3: 131-156.

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