As digital instrumentation in Nuclear Power Plants (NPPs) is becoming increasingly complex, both attack vectors and defensive strategies are evolving based on new technologies and vulnerabilities. Continued efforts have been made to develop a variety of measures for the cyber defense of these infrastructures, which often consist in adapting security measures previously developed for other critical infrastructure sectors according to the requirements of NPPs. That being said, due to the very recent development of these solutions, there is a lack of agreement or standardization when it comes to their adoption at an industrial level. To better understand the state of the art in NPP Cyber-Security (CS) measures, in this work, we conduct a Systematic Literature Review (SLR) to identify scientific papers discussing CS frameworks, standards, guidelines, best practices, and any additional CS protection measures for NPPs. From our literature analysis, it was evidenced that protecting the digital space in NPPs involves three main steps: (i) identification of critical digital assets; (ii) risk assessment and threat analysis; (iii) establishment of measures for NPP protection based on the defense-in-depth model. To ensure the CS protection of these infrastructures, a holistic defense-in-depth approach is suggested in order to avoid excessive granularity and lack of compatibility between different layers of protection. Additional research is needed to ensure that such a model is developed effectively and that it is based on the interdependencies of all security requirements of NPPs.
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