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Gastrointestinal Disorders
Volume 7
Issue 4
10.3390/gidisord7040067
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This is an early access version, the complete PDF, HTML, and XML versions will be available soon.
Review

Genetic Predisposition and Nutritional Interactions in Gastroenterology: A Review of European Clinical Recommendations

by
Vaios Svolos
1,2,*,
Anastasia Triantafyllou
1,
Georgios Charmantzis
1,
Maria Delliou
1,
Maria-Nikoletta Nanti
1,
Melina Moustaka
1,
Eleni Bakasieta
1,
Evanthia Balafa
1,
Dimitra Eleftheria Strongylou
1 and
Odysseas Androutsos
1
1
Laboratory of Clinical Nutrition and Dietetics, Department of Nutrition and Dietetics, School of Physical Education, Sports Science and Dietetics, University of Thessaly, 42100 Trikala, Greece
2
School of Medicine, Dentistry and Nursing, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8QF, UK
*
Author to whom correspondence should be addressed.
Gastrointest. Disord. 2025, 7(4), 67; https://doi.org/10.3390/gidisord7040067
Submission received: 1 September 2025 / Revised: 6 October 2025 / Accepted: 10 October 2025 / Published: 17 October 2025
Versions Notes

Abstract

Background/Objectives: Despite the growing understanding of the relationship between the genome and nutrition, clearly defined and evidence-based clinical guidelines remain insufficient. The objective of this review was to identify and compile all available European guidelines related to the impact of genetic predisposition on nutritional recommendations in the field of gastroenterology. Methods: A review of guidelines and position papers issued by four European organisations [the European Crohn’s and Colitis Organisation (ECCO), the European Society for Paediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN), the European Society for Clinical Nutrition and Metabolism (ESPEN), and United European Gastroenterology (UEG)] was conducted for the past ten years. Results: Out of 5196 recommendations and statements extracted from 124 manuscripts, only 13 highlighted a link between genetic predisposition and dietary factors in clinical gastroenterology. From the available guidelines, there is no clear trend indicating an increased focus on genetic background and its association with nutrition in recent years. Conclusions: There is a critical opportunity for European organisations to develop an evidence-based information framework, guided by clinical protocols, in order to integrate the large volume of genetic data into clinical practice and personalised care of individuals with gastrointestinal disorders.
Keywords: nutrigenetics; nutrigenomics; genome; genetics; genetic predisposition; nutrition; diet; gastroenterology nutrigenetics; nutrigenomics; genome; genetics; genetic predisposition; nutrition; diet; gastroenterology

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MDPI and ACS Style

Svolos, V.; Triantafyllou, A.; Charmantzis, G.; Delliou, M.; Nanti, M.-N.; Moustaka, M.; Bakasieta, E.; Balafa, E.; Strongylou, D.E.; Androutsos, O. Genetic Predisposition and Nutritional Interactions in Gastroenterology: A Review of European Clinical Recommendations. Gastrointest. Disord. 2025, 7, 67. https://doi.org/10.3390/gidisord7040067

AMA Style

Svolos V, Triantafyllou A, Charmantzis G, Delliou M, Nanti M-N, Moustaka M, Bakasieta E, Balafa E, Strongylou DE, Androutsos O. Genetic Predisposition and Nutritional Interactions in Gastroenterology: A Review of European Clinical Recommendations. Gastrointestinal Disorders. 2025; 7(4):67. https://doi.org/10.3390/gidisord7040067

Chicago/Turabian Style

Svolos, Vaios, Anastasia Triantafyllou, Georgios Charmantzis, Maria Delliou, Maria-Nikoletta Nanti, Melina Moustaka, Eleni Bakasieta, Evanthia Balafa, Dimitra Eleftheria Strongylou, and Odysseas Androutsos. 2025. "Genetic Predisposition and Nutritional Interactions in Gastroenterology: A Review of European Clinical Recommendations" Gastrointestinal Disorders 7, no. 4: 67. https://doi.org/10.3390/gidisord7040067

APA Style

Svolos, V., Triantafyllou, A., Charmantzis, G., Delliou, M., Nanti, M.-N., Moustaka, M., Bakasieta, E., Balafa, E., Strongylou, D. E., & Androutsos, O. (2025). Genetic Predisposition and Nutritional Interactions in Gastroenterology: A Review of European Clinical Recommendations. Gastrointestinal Disorders, 7(4), 67. https://doi.org/10.3390/gidisord7040067

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