Next Article in Journal
The Role of Vitamin D in the Pathogenesis of Inflammatory Bowel Disease
Previous Article in Journal
Determination of Tumor Location in Rectosigmoid Carcinomas: Difficulties in Preoperative Diagnostics
Open AccessArticle

The Predictive Factors of Responsiveness to Proton Pump Inhibitor Therapy for Eosinophilic Esophagitis

Department of Gastroenterology, Osaka City University Graduate School of Medicine, Osaka 545-8585, Japan
*
Author to whom correspondence should be addressed.
Gastrointest. Disord. 2019, 1(1), 220-230; https://doi.org/10.3390/gidisord1010017
Received: 10 January 2019 / Revised: 18 February 2019 / Accepted: 21 February 2019 / Published: 25 February 2019
Approximately half of patients with eosinophilic esophagitis (EoE) respond clinically and histologically to proton pump inhibitor (PPI) therapy. Although recent guidelines suggest that PPI-responders and non-responders were included in EoE, it is important to investigate the predictive factors of PPI- responsiveness. This study aimed to determine the rate of PPI- responders and compare the characteristics of PPI-responders and non-responders. Fifty-nine patients with esophageal eosinophilia received PPI therapy for eight weeks, and its efficacy was assessed. PPI- responsiveness was diagnosed based on the relief in symptoms and reduction of intraepithelial eosinophilic infiltration to <15 per high-power field (hpf) after PPI therapy. Multivariate analysis was performed to identify factors associated with PPI-responders. Of the 59 patients, 41 (69.5%) were diagnosed with PPI-responders. The rate of gastrointestinal (GI) screening in the indications for endoscopy was significantly higher in patients with PPI- responders than in those with non-responders. On multivariate analysis, GI screening and presence of reflux esophagitis was associated with an increased odds ratio (OR) of PPI-responders, but presence of rings with a decreased OR of PPI-responders. Presence of reflux esophagitis and absence of rings on endoscopy especially during GI screening might be significant predictive factors for PPI response in patients with EoE. View Full-Text
Keywords: esophagus; eosinophilic esophagitis; proton pump inhibitor esophagus; eosinophilic esophagitis; proton pump inhibitor
Show Figures

Figure 1

MDPI and ACS Style

Hashimoto, A.; Sugawa, T.; Iwakura, N.; Uemura, R.; Sawada, A.; Otani, K.; Taira, K.; Hosomi, S.; Nagami, Y.; Tanaka, F.; Kamata, N.; Yamagami, H.; Tanigawa, T.; Watanabe, T.; Fujiwara, Y. The Predictive Factors of Responsiveness to Proton Pump Inhibitor Therapy for Eosinophilic Esophagitis. Gastrointest. Disord. 2019, 1, 220-230.

Show more citation formats Show less citations formats

Article Access Map by Country/Region

1
Back to TopTop