Next Article in Journal
Histopathology of Barrett’s Esophagus and Early-Stage Esophageal Adenocarcinoma: An Updated Review
Next Article in Special Issue
The Role of Vitamin D in the Pathogenesis of Inflammatory Bowel Disease
Previous Article in Journal
Paradigm Shift of Healthcare Cost for Patients with Inflammatory Bowel Diseases: A Claims Data-Based Analysis in Japan
Previous Article in Special Issue
The Multifactorial Etiopathogeneses Interplay of Inflammatory Bowel Disease: An Overview
Open AccessReview

Pathogenesis of Inflammatory Bowel Disease: Basic Science in the Light of Real-World Epidemiology

Department of Medical Science, Turin University, 10126 Turin, Italy
Department of General and Specialist Medicine, Molinette Medical Center, 10126 Turin, Italy
The Medical Center and Turin General Hospitals, 10100 Turin, Italy
Author to whom correspondence should be addressed.
Gastrointest. Disord. 2019, 1(1), 129-146;
Received: 26 August 2018 / Revised: 5 November 2018 / Accepted: 7 November 2018 / Published: 12 November 2018
Major advances in the last few decades have favored the view of inflammatory bowel disease (IBD) as a disease of hyper- or, more often, paradoxical hyporesponsiveness of the gut-associated immune system. The relevant pivot seems to be the loss of the balance between gut-associated pro-inflammatory lymphocytes and the indwelling microbiome species, with inner regulatory circuits (regulatory T-lymphocytes, T-reg) and outer factors (such as drugs, tobacco, diet components) contributing to complicate the matter. Light might be shed by the observation of the real-world IBD epidemiology, which may help unveil the factors that tend to cluster IBD cases to certain geographical areas. A transitional mind frame between bench and real-world gastroenterology could hopefully contribute to restrain the mounting epidemic of IBD in the Western world and to halt the more recent increases seen in many Eastern countries. View Full-Text
Keywords: pathogenesis; inflammatory bowel disease; epidemiology pathogenesis; inflammatory bowel disease; epidemiology
Show Figures

Figure 1

MDPI and ACS Style

Ribaldone, D.G.; Pellicano, R.; Actis, G.C. Pathogenesis of Inflammatory Bowel Disease: Basic Science in the Light of Real-World Epidemiology. Gastrointest. Disord. 2019, 1, 129-146.

Show more citation formats Show less citations formats

Article Access Map by Country/Region

Back to TopTop