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Pathogenesis of Inflammatory Bowel Disease: Basic Science in the Light of Real-World Epidemiology

1
Department of Medical Science, Turin University, 10126 Turin, Italy
2
Department of General and Specialist Medicine, Molinette Medical Center, 10126 Turin, Italy
3
The Medical Center and Turin General Hospitals, 10100 Turin, Italy
*
Author to whom correspondence should be addressed.
Gastrointest. Disord. 2019, 1(1), 129-146; https://doi.org/10.3390/gidisord1010010
Received: 26 August 2018 / Revised: 5 November 2018 / Accepted: 7 November 2018 / Published: 12 November 2018
Major advances in the last few decades have favored the view of inflammatory bowel disease (IBD) as a disease of hyper- or, more often, paradoxical hyporesponsiveness of the gut-associated immune system. The relevant pivot seems to be the loss of the balance between gut-associated pro-inflammatory lymphocytes and the indwelling microbiome species, with inner regulatory circuits (regulatory T-lymphocytes, T-reg) and outer factors (such as drugs, tobacco, diet components) contributing to complicate the matter. Light might be shed by the observation of the real-world IBD epidemiology, which may help unveil the factors that tend to cluster IBD cases to certain geographical areas. A transitional mind frame between bench and real-world gastroenterology could hopefully contribute to restrain the mounting epidemic of IBD in the Western world and to halt the more recent increases seen in many Eastern countries. View Full-Text
Keywords: pathogenesis; inflammatory bowel disease; epidemiology pathogenesis; inflammatory bowel disease; epidemiology
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Ribaldone, D.G.; Pellicano, R.; Actis, G.C. Pathogenesis of Inflammatory Bowel Disease: Basic Science in the Light of Real-World Epidemiology. Gastrointest. Disord. 2019, 1, 129-146.

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