Negative Chronotropic Effects of Class I Antiarrhythmic Drugs on Guinea Pig Right Atria: Correlation with L-Type Ca2+ Channel Blockade
Abstract
:1. Introduction
2. Materials and Methods
2.1. Measurement of Beating Rate
2.2. Drugs and Chemicals
2.3. Statistics
3. Results
4. Discussion
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Therapeutic Concentration Range | IC50 for Negative Chronotropy * | IC50 for Na+ Channel | IC50 for Ca2+ Channel | IC50 for K+ Channel | ||||||
---|---|---|---|---|---|---|---|---|---|---|
Ia | Cibenzoline | 0.8–3.0 | [9] | 28.3 | 7.8 | [10] | 14 | [10] | 3.7 | [11] |
Disopyramide | 5.9–14.7 | [12] | 132.2 | 32 | [13] | 100 | [13] | 7.3 | [14] | |
Ib | Aprindine | 0.4–2.1 | [9] | 28.8 | 0.74 | [10] | 10 | [10] | 0.23 | [15] |
Mexiletine | 2.8–11.1 | [12] | 217.6 | 30 | [16] | 85.74 | [17] | 3.7 | [18] | |
Ic | Flecainide | 0.48–2.4 | [12] | 32.0 | 10.4 | [19] | 27.1 | [20] | 1.5 | [21] |
Pilsicainide | 0.73–3.67 | [9] | 174.5 | 0.88 | [16] | >100 | [22] | 20.4 | [23] | |
Propafenone | 0.27–9.58 | [24] | 37.2 | 1 | [25] | 5 | [26] | 0.55 | [27] | |
Id | Ranolazine | 2–8 | [28] | 128.0 | 428 | [25] | 50 | [29] | 11.5 | [29] |
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Hiiro, H.; Otsuka, K.; Hamaguchi, S.; Namekata, I.; Tanaka, H. Negative Chronotropic Effects of Class I Antiarrhythmic Drugs on Guinea Pig Right Atria: Correlation with L-Type Ca2+ Channel Blockade. J 2023, 6, 104-114. https://doi.org/10.3390/j6010008
Hiiro H, Otsuka K, Hamaguchi S, Namekata I, Tanaka H. Negative Chronotropic Effects of Class I Antiarrhythmic Drugs on Guinea Pig Right Atria: Correlation with L-Type Ca2+ Channel Blockade. J. 2023; 6(1):104-114. https://doi.org/10.3390/j6010008
Chicago/Turabian StyleHiiro, Haruhito, Kentaro Otsuka, Shogo Hamaguchi, Iyuki Namekata, and Hikaru Tanaka. 2023. "Negative Chronotropic Effects of Class I Antiarrhythmic Drugs on Guinea Pig Right Atria: Correlation with L-Type Ca2+ Channel Blockade" J 6, no. 1: 104-114. https://doi.org/10.3390/j6010008