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Inflammation and Peripheral Arterial Disease

Department of Clinical and Experimental Medicine School of Medicine, University of Catania, 95122 Catania, Italy
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J 2019, 2(2), 142-151; https://doi.org/10.3390/j2020012
Received: 24 January 2019 / Revised: 6 March 2019 / Accepted: 29 March 2019 / Published: 3 April 2019
(This article belongs to the Special Issue Atherosclerosis: Molecular Mechanisms and Therapeutic Advances)
Peripheral arterial disease (PAD) is an atherosclerotic disease closely associated with high morbidity and mortality in cardiac events. Inflammation is crucial in atherosclerosis both at triggering and in progression. Numerous inflammatory biomarkers (cytokines, matrix metalloproteinases (MMPs), selectin, intracellular adhesion molecule (ICAM), vascular cell adhesion molecule (VCAM) C-reactive protein (CRP), fibrinogen) have been measured in atherosclerotic diseases including PAD. This paper summarizes the data on the inflammatory biomarkers for PAD pathophysiology and highlights the most useful markers in monitoring PAD outcomes. View Full-Text
Keywords: inflammation; peripheral arterial disease; biomarkers inflammation; peripheral arterial disease; biomarkers
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Signorelli, S.S.; Marino, E.; Scuto, S. Inflammation and Peripheral Arterial Disease. J 2019, 2, 142-151.

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