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Open AccessArticle

Relationship between the Use of Parabens and Allergic Diseases in Japanese Adults—A Cross-Sectional Study

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Department of Environmental and Preventive Medicine, Kanazawa University Graduate School of Medical Sciences, 13-1 Takara-machi, Kanazawa, Ishikawa 920-8640, Japan
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Faculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan
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Department of Health and Safety Sciences, Osaka Kyoiku University, 4-698-1 Asahigaoka, Kashiwara, Osaka 582-8582, Japan
4
Clinical Research Center for Allergy and Rheumatology, Sagamihara National Hospital, 18-1 Sakuradai, Minami-ku, Sagamihara, Kanagawa 252-0392, Japan
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Division of Allergy, Department of Medical Subspecialties, National Center for Child Health and Development, 2-10-1 Okura, Setagaya-ku, Tokyo 157-8535, Japan
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Department of Epidemiology and Environmental Health, Juntendo University Faculty of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan
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The Graduate School of Health Science, Matsumoto University, 2095-1 Niimura, Matsumoto, Nagano 390-1295, Japan
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Third Department of Internal Medicine, University of Fukui Faculty of Medical Sciences, 23-3 Matsuoka Shimoaizaki, Eiheiji-cho, Yoshida-gun, Tsuruga, Fukui 914-0055, Japan
9
Advanced Preventive Medical Center, Kanazawa University, 13-1 Takara-machi, Kanazawa, Ishikawa 920-8640, Japan
*
Author to whom correspondence should be addressed.
J 2018, 1(1), 148-158; https://doi.org/10.3390/j1010014
Received: 28 September 2018 / Revised: 26 October 2018 / Accepted: 30 October 2018 / Published: 4 November 2018
(This article belongs to the Special Issue Feature Papers for J-Multidisciplinary Scientific Journal)
It currently remains unclear whether parabens, which are preservatives added to cosmetics, shampoos, and personal care products that exhibit biocidal activities, exert allergic effects in adults. The aim of the present study was to examine the relationship between the use of parabens and the prevalence of allergic diseases in Japanese adults. This population-based cross-sectional study comprised 2005 participants aged 40 years or older living in Shika Town in Japan who answered a self-administered questionnaire on allergic diseases and the daily use of household goods. The information obtained was then analyzed to assess the exposure to parabens (response rate: 77.9%). The prevalence of nasal allergies, atopic conjunctivitis, and total allergies was significantly higher in women who used parabens. These differences remained significant after adjustments for confounding factors including age, body mass index, smoking, alcohol, exercise, sleep, income, education, and marital status. No relationship between the prevalence of atopic dermatitis and the use of parabens was observed in men or women. However, the present results demonstrated that the prevalence of nasal allergies and atopic conjunctivitis was associated with use of parabens in women, suggesting that parabens may induce allergic responses. View Full-Text
Keywords: allergy; asthma; atopic conjunctivitis; nasal allergies; paraben; triclosan allergy; asthma; atopic conjunctivitis; nasal allergies; paraben; triclosan
MDPI and ACS Style

Shimizu, Y.; Kambayashi, Y.; Tsujiguchi, H.; Hara, A.; Hori, D.; Thi Thu Nguyen, T.; Suzuki, F.; Hamagishi, T.; Yamada, Y.; Nakamura, H.; Yoshikawa, T.; Hayashi, K.; Hibino, Y.; Shibata, A.; Fukutomi, Y.; Ohya, Y.; Yamamoto-Hanada, K.; Muto, G.; Hirota, R.; Konoshita, T.; Nakamura, H. Relationship between the Use of Parabens and Allergic Diseases in Japanese Adults—A Cross-Sectional Study. J 2018, 1, 148-158.

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