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Systematic Review

The Extent of Insulin Resistance in Patients That Cleared Viral Hepatitis C Infection and the Role of Pre-Existent Type 2 Diabetes Mellitus: A Meta-Analysis

by
Marian-Sorin Popescu
1,†,
Andrei Ioan Drocas
2,†,
Andrei Osman
3,†,
Dan-Mihai Firu
1,
Vlad Pădureanu
1,
Cristina Maria Mărginean
1,
Daniel-Cristian Pîrvu
1,
Radu Mitruț
4,
Dragoș Nicolae Mărgăritescu
5,
Antonia Radu
6,
Daniela Calina
7,
Anca Oana Docea
8,* and
Paul Mitruț
1
1
Department of Medical Semiology, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania
2
Department of Urology, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania
3
Department of Anatomy and Embryology, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania
4
Department of Cardiology, University and Emergency Hospital, 050098 Bucharest, Romania
5
Department of Surgery, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania
6
Department of Pharmaceutical Botany, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania
7
Department of Clinical Pharmacy, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania
8
Department of Toxicology, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania
*
Author to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Reports 2022, 5(4), 42; https://doi.org/10.3390/reports5040042
Submission received: 26 August 2022 / Revised: 10 October 2022 / Accepted: 12 October 2022 / Published: 25 October 2022
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Abstract

A high risk of developing insulin resistance (IR) and, eventually, type 2 diabetes mellitus (T2DM) is associated with chronic hepatitis C virus (HCV). Multiple mechanisms can account for the development of IR in chronic HCV patients, steatosis or fatty liver that can lead to metabolic syndrome, and the inflammatory process associated with the presence of HCV infection. In this article, we analyze the reported values of homoeostasis model assessment (HOMA-IR) before and after successful direct-acting agents (DAAs) treatment in the literature (23 studies) at certain intervals, respectively 12, 24, and 52 weeks depending on the presence of T2DM among patients. The meta-analysis showed improvement of IR in most cases except for three studies that presented a minimal increase in HOMA-IR value for the non-T2DM group at the 12- and 24-week check-ups possibly hinting at a prediabetes group. All other studies showed an important decrease in HOMA-IR post-DAA treatment specifically for the T2DM group. The most significant change in HOMA-IR values was noticed after 24 weeks in all categories. Our meta-analysis showed that clearance of HCV leads to improvement of IR, especially in the case of patients with T2DM.
Keywords: hepatitis C; insulin resistance; diabetes; meta-analysis hepatitis C; insulin resistance; diabetes; meta-analysis

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MDPI and ACS Style

Popescu, M.-S.; Drocas, A.I.; Osman, A.; Firu, D.-M.; Pădureanu, V.; Mărginean, C.M.; Pîrvu, D.-C.; Mitruț, R.; Mărgăritescu, D.N.; Radu, A.; et al. The Extent of Insulin Resistance in Patients That Cleared Viral Hepatitis C Infection and the Role of Pre-Existent Type 2 Diabetes Mellitus: A Meta-Analysis. Reports 2022, 5, 42. https://doi.org/10.3390/reports5040042

AMA Style

Popescu M-S, Drocas AI, Osman A, Firu D-M, Pădureanu V, Mărginean CM, Pîrvu D-C, Mitruț R, Mărgăritescu DN, Radu A, et al. The Extent of Insulin Resistance in Patients That Cleared Viral Hepatitis C Infection and the Role of Pre-Existent Type 2 Diabetes Mellitus: A Meta-Analysis. Reports. 2022; 5(4):42. https://doi.org/10.3390/reports5040042

Chicago/Turabian Style

Popescu, Marian-Sorin, Andrei Ioan Drocas, Andrei Osman, Dan-Mihai Firu, Vlad Pădureanu, Cristina Maria Mărginean, Daniel-Cristian Pîrvu, Radu Mitruț, Dragoș Nicolae Mărgăritescu, Antonia Radu, and et al. 2022. "The Extent of Insulin Resistance in Patients That Cleared Viral Hepatitis C Infection and the Role of Pre-Existent Type 2 Diabetes Mellitus: A Meta-Analysis" Reports 5, no. 4: 42. https://doi.org/10.3390/reports5040042

APA Style

Popescu, M.-S., Drocas, A. I., Osman, A., Firu, D.-M., Pădureanu, V., Mărginean, C. M., Pîrvu, D.-C., Mitruț, R., Mărgăritescu, D. N., Radu, A., Calina, D., Docea, A. O., & Mitruț, P. (2022). The Extent of Insulin Resistance in Patients That Cleared Viral Hepatitis C Infection and the Role of Pre-Existent Type 2 Diabetes Mellitus: A Meta-Analysis. Reports, 5(4), 42. https://doi.org/10.3390/reports5040042

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