Concurrent Hip Pain and Skull Lump as the First Manifestations of a Silent Follicular Thyroid Carcinoma
Round 1
Reviewer 1 Report
The authors present s case study of metastatic thyroid follicular carcinoma with metastases in bones as first clinical signs of malignancy. The case is potentially interested with teaching potential, but the following informations and figures should be added:
- any fine needle aspiration of thyroid gland or skull lesion?
- better pictures of primary tumor to see architecture and growth, proliferation prefomed?, any other IHC staining?
Author Response
Thank you very much for considering our manuscript reports-940050 “Concurrent hip pain and skull lump as the first manifestations of a silent follicular thyroid carcinoma”.
We are very pleased about the overall positive evaluation of our manuscript (“potentially interested, teaching potential, clearly written, of interest for clinicians”). We appreciate all comments raised by the reviewers and editors which provide us an opportunity to improve our manuscript. We are thankful for the offer to resubmit our revised version addressing all reviewer comments and suggestions. A point by point-reply describing all changes made in detail is included. In the revised manuscript, all changes are highlighted in yellow.
Reviewer reports:
Reviewer #1:
- Any fine needle aspiration of thyroid gland or skull lesion?
Comments:
Yes, we have needle aspiration biopsy in the skull and thyroid. Please find our further explanation in the revised manuscript Page 3 line 73-75.
Needle aspiration biopsy guided with sonography in the thyroid revealed follicular neoplasm and needle biopsy from the skull lump indicated metastatic lesions from well-differentiated thyroid carcinoma.
better pictures of primary tumor to see architecture and growth, proliferation prefomed?, any other IHC staining
Comments:
We have revised the Figure 2 as well as the figure legend to show tissue architecture of the follicular thyroid carcinoma. However, we did not perform additional IHC staining in this case. Please find at the revised version Page 5 Line 99-100.
Moderate English changes required.
Comments:
The revised manuscript has been reviewed and corrected by a native English scientist. Please find in the revised manuscript.
Reviewer 2 Report
the article is clearly written. As a case report, il can be of interest for clinicians, and may be also teachers in medical schools.
Author Response
Thank you very much for considering our manuscript reports-940050 “Concurrent hip pain and skull lump as the first manifestations of a silent follicular thyroid carcinoma”.
We are very pleased about the overall positive evaluation of our manuscript (“potentially interested, teaching potential, clearly written, of interest for clinicians”). We appreciate all comments raised by the reviewers and editors which provide us an opportunity to improve our manuscript. We are thankful for the offer to resubmit our revised version addressing all reviewer comments and suggestions. A point by point-reply describing all changes made in detail is included. In the revised manuscript, all changes are highlighted in yellow.
Reviewer #2:
- English language and style are fine / minor spell check required
Comments:
The revised manuscript has been reviewed and corrected by a native English scientist. Please find in the revised manuscript.
