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Plasma 2018, 1(1), 218-228; https://doi.org/10.3390/plasma1010019

Treatment of Triple-Negative Breast Cancer Cells with the Canady Cold Plasma Conversion System: Preliminary Results

1
Jerome Canady Research Institute for Advanced Biological and Technological Sciences, Takoma Park, MD 20912 USA
2
School of Aeronautics and Astronautics, Purdue University, West Lafayette, IN 47907, USA
3
Plasma Medicine Life Sciences, Takoma Park, MD 20912, USA
4
Department of Surgery, University of Massachusetts School of Medicine, Worcester, MA 01655, USA
5
School of Engineering and Applied Science, The George Washington University, Washington, DC 20052, USA
The authors have contributed equally.
*
Author to whom correspondence should be addressed.
Received: 27 July 2018 / Revised: 10 September 2018 / Accepted: 10 September 2018 / Published: 15 September 2018
(This article belongs to the Special Issue Plasma Medicine)
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Abstract

Triple-negative breast cancer is a phenotype of breast cancer where the expression level of estrogen, progesterone and human epidermal growth factor receptor 2 (HER2) receptors are low or absent. It is more frequently diagnosed in younger and premenopausal women, among which African and Hispanic have a higher rate. Cold atmospheric plasma has revealed its promising ant-cancer capacity over the past two decades. In this study, we report the first cold plasma jet delivered by the Canady Cold Plasma Conversion Unit and characterization of its electric and thermal parameters. The unit effectively reduced the viability of triple-negative breast cancer up to 80% without thermal damage, providing a starting point for future clinical trials. View Full-Text
Keywords: triple-negative breast cancer; cold atmospheric plasma; cold plasma device triple-negative breast cancer; cold atmospheric plasma; cold plasma device
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Cheng, X.; Rowe, W.; Ly, L.; Shashurin, A.; Zhuang, T.; Wigh, S.; Basadonna, G.; Trink, B.; Keidar, M.; Canady, J. Treatment of Triple-Negative Breast Cancer Cells with the Canady Cold Plasma Conversion System: Preliminary Results. Plasma 2018, 1, 218-228.

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