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Open AccessArticle

Osteogenic Enhancement of Zirconia-Toughened Alumina with Silicon Nitride and Bioglass®

1
Ceramic Physics Laboratory, Kyoto Institute of Technology, Sakyo-ku, Matsugasaki, Kyoto 606-8585, Japan
2
Department of Immunology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kamigyo-ku, 465 Kajii-cho, Kyoto 602-8566, Japan
3
Department of Orthopedic Surgery, Tokyo Medical University, 6-7-1 Nishi-Shinjuku, Shinjuku-ku, Tokyo 160-0023, Japan
4
The Center for Advanced Medical Engineering and Informatics, Osaka University, 2-2 Yamadaoka, Suita, Osaka 565-0854, Japan
5
Department of Dental Medicine, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kamigyo-ku, Kyoto 602-8566, Japan
6
SINTX Technologies Corporation, 1885 West 2100 South, Salt Lake City, UT 84119, USA
*
Author to whom correspondence should be addressed.
Ceramics 2019, 2(4), 554-567; https://doi.org/10.3390/ceramics2040043
Received: 28 August 2019 / Revised: 19 September 2019 / Accepted: 30 September 2019 / Published: 4 October 2019
(This article belongs to the Special Issue Ceramics for Biomedical Applications)
Alumina (Al2O3) ceramic implants do not stimulate osteoblasts in vivo. Surface alterations targeted at changing the chemistry or topography have been proposed to enhance the bioactivity of alumina. This surface modification is intended to improve oxide bioceramic’s ability to integrate with the biological environment and, in particular, to rapidly osteointegrate. In this study, the surface of zirconia-toughened alumina (ZTA) was functionalized using two methods: (i) Surface laser-patterning and successive filling of patterned wells with powder mixtures of bioglass and Si3N4; and, (ii) Si3N4 coating by pulse-laser sintering. Functionalized ZTA surfaces were characterized with vibrational spectroscopy, biological testing, and laser microscopy. Both enhancements resulted in osteoblast activation, a property that is relevant to osteosynthesis.
Keywords: zirconia-toughened alumina; silicon nitride; surface functionalization; pulsed laser technology; osteogenesis zirconia-toughened alumina; silicon nitride; surface functionalization; pulsed laser technology; osteogenesis
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Pezzotti, G.; Marin, E.; Zanocco, M.; Boschetto, F.; Zhu, W.; McEntire, B.J.; Bal, B.S.; Adachi, T.; Yamamoto, T.; Mazda, O. Osteogenic Enhancement of Zirconia-Toughened Alumina with Silicon Nitride and Bioglass®. Ceramics 2019, 2, 554-567.

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