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Volume 87
Issue 4
10.5603/ARM.2019.0037
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Advances in Respiratory Medicine is published by MDPI from Volume 90 Issue 4 (2022). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Via Medica.
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Article

The TNF-α, P53 Protein Response and Lung Respiratory Changes Related to Exercise, Chronic Hypoxia and Adiantum capillus-Veneris Supplementation

by
Mehdi Yadegari
1,
Simin Riahy
2,
Shadmehr Mirdar
1,
Gholamreza Hamidian
3,
Seyed Mohsen Afkhami
4,
Ayoub Saeidi
5,
Fatma Rhibi
6,
Abderraouf Ben Abderrahman
7,
Anthony C. Hackney
8 and
Hassane Zouhal
6,*
1
Department of Exercise Physiology, Faculty of Physical Education and Sport Sciences, University of Mazandaran, Mazandaran, Iran
2
Faculty of Aerospace Medicine and Subsurface, Army Medical University, Tehran, Iran
3
Department of Basic Sciences, Faculty of Veterinary Medicine, University of Tabriz, Tabriz, Iran
4
Colonel Physician, Army Ground Forces, Health Relief and Treatment Center, Teheran, Iran
5
Department of Biological Sciences in Sport, Faculty of Sports Sciences and Health, Shahid Beheshti University, Teheran, Iran
6
Université de Rennes, M2S, Laboratoire Mouvement, Sport, Santé, Rennes, France
7
Higher Institutes of Sport and Physical Education of Ksar-Said, Ksar-Said, Tunisia
8
Department of Exercise & Sport Science, University of North Carolina, Chapel Hill, NC, USA
*
Author to whom correspondence should be addressed.
Adv. Respir. Med. 2019, 87(4), 226-234; https://doi.org/10.5603/ARM.2019.0037
Submission received: 23 December 2018 / Revised: 16 July 2019 / Accepted: 16 July 2019 / Published: 30 August 2019

Abstract

Introduction: Evidence suggests that hypoxia and high-intensity exercise training can increase apoptosis of lung cells and Adiantum capillus-veneris (Ac-v) extract can have anti-apoptotic effects. Thus, the aim of the present study was to investigate the effect of chronic hypoxia and the (Ac-v) extraction as a supplement on TNF-a and P53 protein expression as well as the respiratory surface. Material and methods: 24 healthy Wistar rats (age = 4 weeks, weight = 72 = 9 gr) were trained using interval training for 6 weeks followed by a 3-week stay in hypoxia conditions. Half of the hypoxia samples received 500 ml/gr/per body weight daily (Ac-v) within 3 weeks of hypoxia. At the end, the lung tissue was removed for histological and immunohistological analysis. Results: After 3 weeks of hypoxia exposure following 6 weeks of exercise, expression of P53 and TNF-a increased and the respiratory surface decreased (p ≤ 0.05). After 3 weeks of taking the Ac-v extract during hypoxia exposure, reduced P53 and TNF-a expression and the increased respiratory surface were observed (p ≤ 0.05). Conclusions: Chronic hypoxia may be considered as a strong stimulus leading to the expression of proteins involved in apoptosis and tissue disruption. However, our findings suggest that the antioxidative properties of Ac-v extract could decrease the destructive structural and molecular events that happen along with hypoxia exposure or intense exercise training.
Keywords: apoptosis; lung; interval training; respiratory surface apoptosis; lung; interval training; respiratory surface

Share and Cite

MDPI and ACS Style

Yadegari, M.; Riahy, S.; Mirdar, S.; Hamidian, G.; Afkhami, S.M.; Saeidi, A.; Rhibi, F.; Ben Abderrahman, A.; Hackney, A.C.; Zouhal, H. The TNF-α, P53 Protein Response and Lung Respiratory Changes Related to Exercise, Chronic Hypoxia and Adiantum capillus-Veneris Supplementation. Adv. Respir. Med. 2019, 87, 226-234. https://doi.org/10.5603/ARM.2019.0037

AMA Style

Yadegari M, Riahy S, Mirdar S, Hamidian G, Afkhami SM, Saeidi A, Rhibi F, Ben Abderrahman A, Hackney AC, Zouhal H. The TNF-α, P53 Protein Response and Lung Respiratory Changes Related to Exercise, Chronic Hypoxia and Adiantum capillus-Veneris Supplementation. Advances in Respiratory Medicine. 2019; 87(4):226-234. https://doi.org/10.5603/ARM.2019.0037

Chicago/Turabian Style

Yadegari, Mehdi, Simin Riahy, Shadmehr Mirdar, Gholamreza Hamidian, Seyed Mohsen Afkhami, Ayoub Saeidi, Fatma Rhibi, Abderraouf Ben Abderrahman, Anthony C. Hackney, and Hassane Zouhal. 2019. "The TNF-α, P53 Protein Response and Lung Respiratory Changes Related to Exercise, Chronic Hypoxia and Adiantum capillus-Veneris Supplementation" Advances in Respiratory Medicine 87, no. 4: 226-234. https://doi.org/10.5603/ARM.2019.0037

APA Style

Yadegari, M., Riahy, S., Mirdar, S., Hamidian, G., Afkhami, S. M., Saeidi, A., Rhibi, F., Ben Abderrahman, A., Hackney, A. C., & Zouhal, H. (2019). The TNF-α, P53 Protein Response and Lung Respiratory Changes Related to Exercise, Chronic Hypoxia and Adiantum capillus-Veneris Supplementation. Advances in Respiratory Medicine, 87(4), 226-234. https://doi.org/10.5603/ARM.2019.0037

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