Synthesis, Spectral Characterization, and Anti-Tumor Activity of Some Pyrazole Derivatives †
by
Christina Marie Zalaru
1,*, 
Maria Marinescu
1,
Florea Dumitrascu
2,
Constantin Draghici
2,
Rodica Tatia
3,
Lucia Moldovan
3,
Alina Constantinescu
1 and
Irina Dumitrescu
1 1
Department of Organic Chemistry, Biochemistry and Catalysis, Faculty of Chemistry, University of Bucharest, 90-92 Panduri Road, Bucharest Romania, RO-050663 Bucharest, Romania
2
Institute of Organic Chemistry “C.D. Nenitescu”, 202B Spl Independentei, RO-060023 Bucharest, Romania
3
Department of Cellular and Molecular Biology, National Institute of Research and Development for Biological Sciences, 296 Splaiul Independenţei, RO-060031 Bucharest, Romania
*
Author to whom correspondence should be addressed.
†
Presented at the 16th International Symposium “Priorities of Chemistry for a Sustainable Development” PRIOCHEM, Bucharest, Romania, 28–30 October 2020.
Proceedings 2020, 57(1), 98; https://doi.org/10.3390/proceedings2020057098
Published: 18 November 2020
(This article belongs to the Proceedings of The 16th International Symposium “Priorities of Chemistry for a Sustainable Development” PRIOCHEM)
1. Introduction
Cancer is a terrible disease that is spread around the world. Chemotherapy remains a significant way of treating cancerous diseases. Although some impressive progress has been made in cancer therapy, drug resistance and toxicity, the development of new anticancer chemotherapeutic agents is being sought [1,2].
2. Materials and Methods
Commercial reagents have been used in the synthesis of intermediate pyrazolic compounds. All synthesized pyrazolic compounds were characterized by IR, 1H-NMR 13C-NMR, UV-Vis, MS, elemental analysis, and tested in vitro for their anti-tumor activity.
3. Results
In this study three series of pyrazole derivatives were synthesized in two steps with good yields:
In the first step, pyrazoles reacted with a aqueous 30% formaldehyde solution to give the 1-(hydroxymethyl)pyrazole derivatives [3]. In the second step, the 1-hydroxymethyl-pyrazoles reacted with, aromatic amines giving pyrazole Mannich bases [4,5].
The structures of all compounds were confirmed by 1H, 13C-NMR, FTIR, UV-VIS spectra and elemental analysis.
Some compounds were tested in vitro for their cytotoxic activity on normal NCTC cells, and their anti-tumor activity in a culture of human cervix carcinoma Hep-2 cells at different concentrations of the sample for 48 h.
Some new benzimidazole Mannich bases was synthesized and characterized [6].
References
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MDPI and ACS Style
Zalaru, C.M.; Marinescu, M.; Dumitrascu, F.; Draghici, C.; Tatia, R.; Moldovan, L.; Constantinescu, A.; Dumitrescu, I. Synthesis, Spectral Characterization, and Anti-Tumor Activity of Some Pyrazole Derivatives. Proceedings 2020, 57, 98. https://doi.org/10.3390/proceedings2020057098
AMA Style
Zalaru CM, Marinescu M, Dumitrascu F, Draghici C, Tatia R, Moldovan L, Constantinescu A, Dumitrescu I. Synthesis, Spectral Characterization, and Anti-Tumor Activity of Some Pyrazole Derivatives. Proceedings. 2020; 57(1):98. https://doi.org/10.3390/proceedings2020057098
Chicago/Turabian StyleZalaru, Christina Marie, Maria Marinescu, Florea Dumitrascu, Constantin Draghici, Rodica Tatia, Lucia Moldovan, Alina Constantinescu, and Irina Dumitrescu. 2020. "Synthesis, Spectral Characterization, and Anti-Tumor Activity of Some Pyrazole Derivatives" Proceedings 57, no. 1: 98. https://doi.org/10.3390/proceedings2020057098
