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Extended Abstract

Effect of Nigella sativa Oil in a Rat Model of Adjuvant-Induced Arthritis †

by
Cinzia Nasuti
1,
Laura Bordoni
2,
Donatella Fedeli
2 and
Rosita Gabbianelli
2,*
1
Unit of Toxicology and Pharmacology, School of Pharmacy, University of Camerino, 62032 Camerino,Italy
2
Unit of Molecular biology, School of Pharmacy, University of Camerino, 62032 Camerino, Italy
*
Author to whom correspondence should be addressed.
†
Presented at Natural Products and the Hallmarks of Chronic Diseases—COST Action 16112, Luxemburg, 25–27 March 2019.
Proceedings 2019, 11(1), 16; https://doi.org/10.3390/proceedings2019011016
Published: 16 April 2019
(This article belongs to the Proceedings of CA16112 - Luxemburg 2019)
Versions Notes
Rheumatoid arthritis is characterized by chronic progressive inflammation and damage at joints leading to disability in about 250 million people between 30 and 60 years of age. Here we studied the capacity of Nigella sativa oil cultivar; produced in the Marche region (Italy), to slow the onset/progression of disease in an adjuvant-induced arthritis animal model [1]. Nigella sativa oil was chosen for its anti-inflammatory and antioxidant properties previously measured in a human in vitro model of low–grade inflammation [2]. In vitro data showed antioxidant and anti-inflammatory properties of this oil; in particular, IL-1 beta and IL6 levels were decreased by Nigella sativa oil [2]. The in vivo indicated that 25 days of treatment with Nigella sativa oil can reduce the edema of inoculated and contralateral paws in the animal model of arthritis. Anti-hyperalgesic and anti-allodynic actions of Nigella sativa were observed during the anti-inflammatory process. Arthritic scoring was improved only in the positive control treated with indomethacin

Funding

This article is based upon work from COST Action NutRedOx-CA16112 supported by COST (European Cooperation in Science and Technology).

Conflicts of Interest

The authors declare no conflict of interest.

References

  1. Bevaart, L.; Vervoordeldonk, M.J.; Tak, P.P. Evaluation of therapeutic targets in animal models of arthritis: How does it relate to rheumatoid arthritis? Arthritis Rheum. 2010, 62, 2192–2205. [Google Scholar] [CrossRef] [PubMed]
  2. Bordoni, L.; Fedeli, D.; Nasuti, C.; Maggi, F.; Papa, F.; Wabitsch, M.; de Caterina, R.; Gabbianelli, R. Antioxidant and anti-inflammatory properties of Nigella sativa oil in human pre-adipocytes. Antioxidants 2019, 8, 51. [Google Scholar] [CrossRef] [PubMed]

Share and Cite

MDPI and ACS Style

Nasuti, C.; Bordoni, L.; Fedeli, D.; Gabbianelli, R. Effect of Nigella sativa Oil in a Rat Model of Adjuvant-Induced Arthritis. Proceedings 2019, 11, 16. https://doi.org/10.3390/proceedings2019011016

AMA Style

Nasuti C, Bordoni L, Fedeli D, Gabbianelli R. Effect of Nigella sativa Oil in a Rat Model of Adjuvant-Induced Arthritis. Proceedings. 2019; 11(1):16. https://doi.org/10.3390/proceedings2019011016

Chicago/Turabian Style

Nasuti, Cinzia, Laura Bordoni, Donatella Fedeli, and Rosita Gabbianelli. 2019. "Effect of Nigella sativa Oil in a Rat Model of Adjuvant-Induced Arthritis" Proceedings 11, no. 1: 16. https://doi.org/10.3390/proceedings2019011016

APA Style

Nasuti, C., Bordoni, L., Fedeli, D., & Gabbianelli, R. (2019). Effect of Nigella sativa Oil in a Rat Model of Adjuvant-Induced Arthritis. Proceedings, 11(1), 16. https://doi.org/10.3390/proceedings2019011016

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