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Proceedings 2019, 11(1), 15; https://doi.org/10.3390/proceedings2019011015

Antioxidant Properties of S-Nitrosoglutathione and Nanotechnologies

Université de Lorraine, CITHEFOR, F-54000 Nancy, France
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Presented at Natural Products and the Hallmarks of Chronic Diseases—COST Action 16112, Luxemburg, 25–27 March 2019.
Published: 16 April 2019
PDF [206 KB, uploaded 16 April 2019]

Abstract

Cardiovascular diseases are associated with oxidative stress and a reduced bioavailability of nitric oxide (NO). To counteract both processes, the administration of S-nitrosoglutathione (GSNO) can be envisaged. GSNO is able to induce protein S-nitrosation (Pr-SNO), which is a post-translational modification of proteins, participating in the storage of NO in tissues, and protect thiol functions from oxidation. However, GSNO antioxidant power is poorly studied, which is probably linked to its low stability. This low stability can be addressed by nanotechnologies that will increase GSNO protection and provide a sustained release of the drug.
Keywords: S-nitrosoglutathione; oxidative stress; protein S-nitrosation; nanotechnologies S-nitrosoglutathione; oxidative stress; protein S-nitrosation; nanotechnologies
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Parent, M.; Zhou, Y.; Bonetti, J.; Perrin-Sarrado, C.; Lartaud, I.; Sapin-Minet, A.; Gaucher, C. Antioxidant Properties of S-Nitrosoglutathione and Nanotechnologies. Proceedings 2019, 11, 15.

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