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Proceedings 2017, 1(10), 1062;

The Effect of Tocopherol-α on the Cell Viability in Caco-2 Cell Line

Department of Biochemistry, Faculty of Veterinary Medicine, Ankara University, Yenimahalle 06560,Turkey
Presented at the 2nd International Conference on Natural Products for Cancer Prevention and Therapy, Kayseri, Turkey, 8–11 November 2017.
Author to whom correspondence should be addressed.
Published: 16 November 2017
PDF [153 KB, uploaded 17 November 2017]


Tocopherols, the major forms of vitamin E, are a family of fat-soluble phenolic compounds. Each tocopherol contains a chromanol ring system and a phytyl chain containing 16 carbons. Tocopherols, as effective antioxidants, have been proposed to protect against carcinogenesis. Colon carsinoma cell line were treated with tocopherol-α (0, 3.12, 6.25, 12.5, 25, 50, 100, 200 uM). Cell viability and migration were examined. Cell viability was determined MTT assay and cell migration was determined by wound healing assay. Caco-2 cells were treated with for 24 h, 48 h and 72 h incubation. There is a significant decrease was observed at 50, 100 and 200 µM for 48 h and 72 h incubation on cell viability in the MTT assay. Wound healing method observed decrease on migration at 12, 5, 25 and 50 µM in 24 h. These results suggest that tocopherol-α have promising antiproliferative effect on cell viability for research on cancer.
Keywords: Antiproliferative effect; Caco-2 cell line; tocopherol-α. Antiproliferative effect; Caco-2 cell line; tocopherol-α.
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Gök, A.; Kurtdede, E.; Cengiz, R.S.; Kısmalı, G.; Sel, T. The Effect of Tocopherol-α on the Cell Viability in Caco-2 Cell Line. Proceedings 2017, 1, 1062.

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