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Proceedings 2017, 1(10), 1054;

The Antiproliferative Effect of Alpha Tocopherol in F98 Cell Culture

Ankara Unıversıty, Faculty of Veterinary Medicine, İrfan Baştuğ street, Dışkapı 06110, Turkey
Presented at the 2nd International Conference on Natural Products for Cancer Prevention and Therapy, Kayseri, Turkey, 8–11 November 2017.
Author to whom correspondence should be addressed.
Published: 15 November 2017
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Alpha tocopherol is the most common and biologically active form of Vitamin E. The aim of this study was to evaulate the possible antiproliferative effect of alpha tocopherol on F-98 Glioblastoma cells. F-98 glioblastoma cell line was seeded at a density of 50.000/mL per well in 96 well plates in 100 µL medium DMEM. Cells treated with Alpha tocopherol (200,100, 50, 25, 12.5, 6.2, 3.3 µM) for 24 h, 48 h and 72 h incubation. Measurement of Alpha tocopherol treated and control groups’ cell proliferation performed with MTT assay and Wound Healing assay was employed to show migration capacity. MTT Assay data shown are there was significant change in cell viability in 24 h, 48 h and 72 h. However significant decrease was observed at 50, 100 and 200 µM. In the present study, antiproliferative effect of alpha tocopherol was observed via wound healing assay. Our results here show that Alpha Tocopherol maybe a possible avenue for brain cancer treatment.
Keywords: F98; Cancer; Wound Healing; Alpha Tocopherol F98; Cancer; Wound Healing; Alpha Tocopherol
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Cengiz, R.S.; Gök, A.; Kurtdede, E.; Kısmalı, G.; Sel, T. The Antiproliferative Effect of Alpha Tocopherol in F98 Cell Culture. Proceedings 2017, 1, 1054.

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