The Antiproliferative Effect of Alpha Tocopherol in F98 Cell Culture †
Ankara Unıversıty, Faculty of Veterinary Medicine, İrfan Baştuğ street, Dışkapı 06110, Turkey
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Author to whom correspondence should be addressed.
†
Presented at the 2nd International Conference on Natural Products for Cancer Prevention and Therapy, Kayseri, Turkey, 8–11 November 2017.
Proceedings 2017, 1(10), 1054; https://doi.org/10.3390/proceedings1101054
Published: 15 November 2017
(This article belongs to the Proceedings of Proceedings of the 2nd International Conference on Natural Products for Cancer Prevention and Therapy)
Abstract
:Alpha tocopherol is the most common and biologically active form of Vitamin E. The aim of this study was to evaulate the possible antiproliferative effect of alpha tocopherol on F-98 Glioblastoma cells. F-98 glioblastoma cell line was seeded at a density of 50.000/mL per well in 96 well plates in 100 µL medium DMEM. Cells treated with Alpha tocopherol (200,100, 50, 25, 12.5, 6.2, 3.3 µM) for 24 h, 48 h and 72 h incubation. Measurement of Alpha tocopherol treated and control groups’ cell proliferation performed with MTT assay and Wound Healing assay was employed to show migration capacity. MTT Assay data shown are there was significant change in cell viability in 24 h, 48 h and 72 h. However significant decrease was observed at 50, 100 and 200 µM. In the present study, antiproliferative effect of alpha tocopherol was observed via wound healing assay. Our results here show that Alpha Tocopherol maybe a possible avenue for brain cancer treatment.
© 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
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MDPI and ACS Style
Cengiz, R.S.; Gök, A.; Kurtdede, E.; Kısmalı, G.; Sel, T. The Antiproliferative Effect of Alpha Tocopherol in F98 Cell Culture. Proceedings 2017, 1, 1054. https://doi.org/10.3390/proceedings1101054
AMA Style
Cengiz RS, Gök A, Kurtdede E, Kısmalı G, Sel T. The Antiproliferative Effect of Alpha Tocopherol in F98 Cell Culture. Proceedings. 2017; 1(10):1054. https://doi.org/10.3390/proceedings1101054
Chicago/Turabian StyleCengiz, Remzi Soner, Ayşenur Gök, Efe Kurtdede, Görkem Kısmalı, and Tevhide Sel. 2017. "The Antiproliferative Effect of Alpha Tocopherol in F98 Cell Culture" Proceedings 1, no. 10: 1054. https://doi.org/10.3390/proceedings1101054
