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Open AccessCommentary

Antiviral Therapy for the Next Influenza Pandemic

by Aeron C. Hurt 1,2
WHO Collaborating Centre for Reference and Research on Influenza, VIDRL, Peter Doherty Institute for Infection and Immunity, Melbourne, VIC 3000, Australia
Department of Microbiology and Immunology, University of Melbourne, Parkville, VIC 3010, Australia
Trop. Med. Infect. Dis. 2019, 4(2), 67;
Received: 28 February 2019 / Revised: 2 April 2019 / Accepted: 15 April 2019 / Published: 18 April 2019
Influenza antivirals will play a critical role in the treatment of outpatients and hospitalised patients in the next pandemic. In the past decade, a number of new influenza antivirals have been licensed for seasonal influenza, which can now be considered for inclusion into antiviral stockpiles held by the World Health Organization (WHO) and individual countries. However, data gaps remain regarding the effectiveness of new and existing antivirals in severely ill patients, and regarding which monotherapy or combinations of antivirals may yield the greatest improvement in outcomes. Regardless of the drug being used, influenza antivirals are most effective when treatment is initiated early in the course of infection, and therefore in a pandemic, effective strategies which enable rapid diagnosis and prompt delivery will yield the greatest benefits. View Full-Text
Keywords: influenza; antivirals; pandemic; stockpile influenza; antivirals; pandemic; stockpile
MDPI and ACS Style

Hurt, A.C. Antiviral Therapy for the Next Influenza Pandemic. Trop. Med. Infect. Dis. 2019, 4, 67.

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