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Bacterial Resistance in Pneumonia in Developing Countries—A Role for Iron Chelation

1
Department of Pharmacy, East West University, Dhaka 1212, Bangladesh
2
Centre for Nutrition & Food Security, International Centre for Diarrhoeal, Disease Research, Dhaka 1213, Bangladesh
3
Department of Clinical Pharmacy and Pharmacology, University of Dhaka, Dhaka 1000, Bangladesh
4
Royal College Affiliated Hospital for Education and Training Institute, Dhaka 1212, Bangladesh
5
Department of Anesthesia, Pain Management and Perioperative Medicine, Faculty of Medicine, Dalhousie University, Halifax, NS B3H 1X5, Canada
*
Author to whom correspondence should be addressed.
Trop. Med. Infect. Dis. 2019, 4(2), 59; https://doi.org/10.3390/tropicalmed4020059
Received: 3 March 2019 / Revised: 1 April 2019 / Accepted: 4 April 2019 / Published: 10 April 2019
(This article belongs to the Special Issue Globalization and Infectious Diseases)
Pneumonia represents one of the major infectious diseases in developing countries and is associated with high mortality, in particular in children under the age of five. The main causative bacterial agents are Streptococcus pneumoniae and Haemophilus influenzae type B, accounting for 33% and 16%, respectively, of the mortality in under-fives. Iron modulates the immune response in infectious diseases and increased iron levels can lead to complications such as sepsis and multiorgan failure. This review will look into the use of iron chelators in order to reduce microbial growth and attenuate a dysregulated immune response during infection. Our hypothesis is that temporary restriction of iron will lessen the incidence and complication rate of infections like pneumonia and result in a decrease of mortality and morbidity. View Full-Text
Keywords: pneumonia; iron; iron chelation; resistance; antibiotics; sepsis pneumonia; iron; iron chelation; resistance; antibiotics; sepsis
MDPI and ACS Style

Islam, S.; Chisti, M.J.; Ahmed, M.; Anwar, N.; Lehmann, C. Bacterial Resistance in Pneumonia in Developing Countries—A Role for Iron Chelation. Trop. Med. Infect. Dis. 2019, 4, 59.

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