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Advances in the Treatment of Yaws

Clinical Research Department, London School of Hygiene & Tropical Medicine, Keppel Street, London WC1E 7HT, UK
Trop. Med. Infect. Dis. 2018, 3(3), 92;
Received: 31 July 2018 / Revised: 27 August 2018 / Accepted: 27 August 2018 / Published: 29 August 2018
PDF [207 KB, uploaded 29 August 2018]


Yaws is one of the three endemic treponematoses and is recognised by the World Health Organization as a neglected tropical disease. Yaws is currently reported in 15 countries in the Pacific, South-East Asia, West and Central Africa, predominantly affects children, and results in destructive lesions of the skin and soft tissues. For most of the twentieth century penicillin-based treatment was the standard of care and resistance to penicillin has still not been described. Recently, oral azithromycin has been shown to be an effective treatment for yaws, facilitating renewed yaws eradication efforts. Resistance to azithromycin is an emerging threat and close surveillance will be required as yaws eradication efforts are scaled up globally. View Full-Text
Keywords: yaws; Treponema pallidum yaws; Treponema pallidum
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Marks, M. Advances in the Treatment of Yaws. Trop. Med. Infect. Dis. 2018, 3, 92.

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