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Experimental Study on the Biological Effect of Cluster Ion Beams in Bacillus subtilis Spores

1
Takasaki Advanced Radiation Research Institute, National Institutes for Quantum and Radiological Science and Technology (QST), 1233 Watanuki, Takasaki, Gunma 370-1292, Japan
2
Institute of Applied Physics, University of Tsukuba, Tsukuba, Ibaraki 305-8573, Japan
*
Author to whom correspondence should be addressed.
Both authors equally contributed to this work.
Quantum Beam Sci. 2019, 3(2), 8; https://doi.org/10.3390/qubs3020008
Received: 25 March 2019 / Revised: 26 April 2019 / Accepted: 26 April 2019 / Published: 6 May 2019
(This article belongs to the Special Issue Ion Beams in Biology and Medicine)
Cluster ion beams have unique features in energy deposition, but their biological effects are yet to be examined. In this study, we employed bacterial spores as a model organism, established an irradiation method, and examined the lethal effect of 2 MeV C, 4 MeV C2, and 6 MeV C3 ion beams. The lethal effect per particle (per number of molecular ions) was not significantly different between cluster and monomer ion beams. The relative biological effectiveness and inactivation cross section as a function of linear energy transfer (LET) suggested that the single atoms of 2 MeV C deposited enough energy to kill the spores, and, therefore, there was no significant difference between the cluster and monomer ion beams in the cell killing effect under this experimental condition. We also considered the behavior of the atoms of cluster ions in the spores after the dissociation of cluster ions into monomer ions by losing bonding electrons through inelastic collisions with atoms on the surface. To the best of our knowledge, this is the first report to provide a basis for examining the biological effect of cluster ions. View Full-Text
Keywords: cluster ion beam; Bacillus subtilis; spore; lethal effect; TIARA cluster ion beam; Bacillus subtilis; spore; lethal effect; TIARA
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MDPI and ACS Style

Hase, Y.; Satoh, K.; Chiba, A.; Hirano, Y.; Tomita, S.; Saito, Y.; Narumi, K. Experimental Study on the Biological Effect of Cluster Ion Beams in Bacillus subtilis Spores. Quantum Beam Sci. 2019, 3, 8.

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