A 10-Year Single-Center Study of the Clinical Characteristics of Optic Neuritis-Related NMOSD, MS, and Double Seronegative Optic Neuritis, Together with Factors Predicting Visual Outcomes
, Methaphon Chainakul 1, Duanghathai Tangon 2 and Thansit Srisombut 1,2
Round 1
Reviewer 1 Report
Your work covers interesting topics of global actuality. The fact you provide a mixed series of optic neuritis with diverse etiologies and a prolonged follow-up are welcome aspects of your study. (1) There is one simple observation/suggestion to improve the structure of the first three lines of the Abstract. It would be clearer if you remove the parenthesis . Suggest the following format "....three types of optic neuritis: double seronegative optic neuritis (DN-ON), Neuromyelitis optica spectrum disorder-related optic neuritis (NMOSD-ON), and multiple sclerosis-related optic neuritis (MS-ON)....etc"
(2) In the section of Material and Methods a brief comment should be included on what criteria was utilized for the subjects in your series with diagnosis of NMOSD (IPND?) and Multiple Sclerosis (McDonald Criteria, 2010 and 2017?).
(3) It is essential you establish the patients classified as DN-ON did not test positive for anti-MOG antibody, or if there were not tested for such.
Author Response
Point 1: There is one simple observation/suggestion to improve the structure of the first three lines of the Abstract. It would be clearer if you remove the parenthesis . Suggest the following format "....three types of optic neuritis: double seronegative optic neuritis (DN-ON), Neuromyelitis optica spectrum disorder-related optic neuritis (NMOSD-ON), and multiple sclerosis-related optic neuritis (MS-ON)....etc"
Response 1: We have removed the sentences of the line1-3 and rewritten into the format “The study included patients diagnosed with three types of optic neuritis (double seronegative optic neuritis; DN-ON, Neuromyelitis optica spectrum disorder related optic neuritis; NMOSD-ON, and multiple sclerosis related optic neuritis ;MS-ON) at Rajavithi Hospital between 2011…...”as recommended by reviewer.
Point 2: In the section of Material and Methods a brief comment should be included on what criteria was utilized for the subjects in your series with diagnosis of NMOSD (IPND?) and Multiple Sclerosis (McDonald Criteria, 2010 and 2017?).
Response 2: We have add references of the McDonald criteria 2017 as the diagnostic criteria of MS in our revision manuscript. The criteria for NMOSD (IPND) was references from Wingerchuk et al.
(Wingerchuk DM, Banwell B, Bennett JL, Cabre P, Carroll W, Chitnis T, et al. International consensus diagnostic criteria for neuromyelitis optica spectrum disorders. Neurology. 2015;85(2):177-89.)
Point 3: It is essential you establish the patients classified as DN-ON did not test positive for anti-MOG antibody, or if there were not tested for such.
Response 3: In this study, double seronegative optic neuritis (DN-ON) is defined as optic neuritis patients who are seronegative for AQP4 IgG and MOG IgG. This patient subcategory was defined in part of methodology.
English langauge and style: Moderate English changes required
Response: This revision manuscript is redo-proofreading by a professional native-speaker proofreader at our institute.
Reviewer 2 Report
This manuscript by Kemchoknatee et al investigated the clinical characteristics as well as potential factors that may affect good visual recovery of three types of optic neuritis (ON) including NMOSD-ON, DN-ON and MS-ON in Thai patients of the same center, it is suitable for publication with minor revision. I only have one minor comment:
The authors discussed some age, gender related differences in this study, if there is any racial related differences in ON patients in the literature, please give a brief discussion.
Thank you!
Author Response
Point 1: The authors discussed some age, gender related differences in this study, if there is any racial related differences in ON patients in the literature, please give a brief discussion.
Response 1: We have discussed the impact of ethnicity on prognosis of NMOSD-ON based on previous literatures in this revised manuscript.
- Kitley J, Leite MI, Nakashima I, Waters P, McNeillis B, Brown R, et al. Prognostic factors and disease course in aquaporin-4 antibody-positive patients with neuromyelitis optica spectrum disorder from the United Kingdom and Japan. Brain. 2012;135(Pt 6):1834-49.
2. Thompson AJ, Banwell BL, Barkhof F, Carroll WM, Coetzee T, Comi G, et al. Diagnosis of multiple sclerosis: 2017 revisions of the McDonald criteria. Lancet Neurol. 2018;17(2):162-73.
Minor point: English language and style are fine/minor spell check required
Response: This revision manuscript is redo-proofreading by a professional native-speaker proofreader at our institute.
