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Open AccessCase Report

Immunohistochemical Analysis of a Vitreous Membrane Removed from a Patient with Incontinentia Pigmenti-Related Retinal Detachment

1
Department of Ophthalmology, University of Szeged, Koranyi fasor 4-8, H-6701 Szeged, Hungary
2
Department of Medical Genetics, University of Szeged, 6720 Szeged, Hungary
3
Department of Pathology, University of Szeged, 6720 Szeged, Hungary
4
Laboratory for Perception & Cognition and Clinical Neuroscience, Nyírő Gyula Hospital, 1135 Budapest, Hungary
5
Department of Physiology, Faculty of Medicine, University of Szeged, Dóm tér 10, 6720 Szeged, Hungary
*
Author to whom correspondence should be addressed.
Received: 20 July 2019 / Revised: 8 November 2019 / Accepted: 24 December 2019 / Published: 2 January 2020
This is a case history of a 23-year-old woman suffering from incontinentia pigmenti (IP). The patient’s vision in the left eye started to deteriorate due to cataract progression at the age of 22, and by the age of 23, it dropped from 0.9 to 0.04. Ultrasound examination confirmed tractional vitreoretinal membranes. Vitrectomy was performed, therefore, on her left eye. The histological evaluation of vitreous membrane revealed a complex immunophenotype (positivity for glial fibrillary acidic protein (GFAP), vimentin, S-100, anti-pan cytokeratin antibody (AE/AE3), and smooth muscle-specific actin (SMA) to various extents). The right eye remained unsymptomatic throughout this course. Besides being the first to analyze the tractional vitreoretinal membrane in IP with immunohistochemical methods, this case study points out that extreme cases of asymmetric side involvement in IP do exist, even to the point of one eye being completely unsymptomatic. View Full-Text
Keywords: incontinentia pigmenti; epiretinal membrane; immunohistochemistry; hereditary diseases incontinentia pigmenti; epiretinal membrane; immunohistochemistry; hereditary diseases
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Janáky, M.; Hári Kovács, A.; Jánossy, Á.; Török, D.; Ivanyi, B.; Braunitzer, G.; Benedek, G. Immunohistochemical Analysis of a Vitreous Membrane Removed from a Patient with Incontinentia Pigmenti-Related Retinal Detachment. Vision 2020, 4, 5.

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