Omega-3 Index as a Sport Biomarker: Implications for Cardiovascular Health, Injury Prevention, and Athletic Performance
Abstract
:1. Introduction
2. ω-3 Index and Cardiovascular Health in Sports
First Author, Year | Population | Study Design | Intervention with Dosage | Key Findings |
---|---|---|---|---|
Anzalone et al., 2019 [34] | 404 NCAA Division I football players | Retrospective, cross-sectional study | N.A. | - Low O3I in 34% of athletes - >8% O3I in no athletes |
Davinelli et al., 2019 [48] | 257 non-elite runners | Retrospective, observational study | N.A. | - Inverse correlation between O3I and AA/EPA ratio - Gradual decrease in the O3I and increase in AA/EPA ratio with higher weekly running distance |
Davinelli et al., 2023 [49] | 275 non-elite runners | Retrospective, observational study | N.A. | - Association of high values of O3I with the lowest number of running-related injuries |
Drobnic et al., 2017 [41] | 24 summer sports athletes | Randomized, parallel-group study | Supplementation with 760 mg/day or 1140 mg/day ω-3 PUFA for 4 months | - Dose-dependent increase in the content of EPA and DHA in the red blood cells at 4 months - Greater increment in O3I in athletes with lower basal levels |
Heileson et al., 2021 [50] | 66 NCAA American football athletes | Multi-site, non-randomized, parallel-group study | Supplementation with 2000 mg DHA, 560 mg EPA, or 320 mg DPA 4 times per week for a total of 89 days | - Increase in O3I and reduced elevation in serum NF-L levels after supplementation |
Hingley et al., 2017 [51] | 26 trained male subjects | Double-blind, placebo-controlled study | Supplementation with 560 mg DHA and 140 mg EPA/day for 8 weeks | - Increase in O3I and reduced relative oxygen consumption during the cycling time trial after supplementation |
Jaworska et al., 2023 [47] | 24 male long-distance runners | Randomized, placebo-controlled study | Supplementation with 3 g of ω-3 PUFA for 3 weeks | - Improvement in blood lipid profiles and O3I - Reduction in inflammation mediators and cardiac damage markers after the eccentric exercise tests |
Larkin et al., 2024 [43] | 47 American college football players | Longitudinal and cross-sectional study | Supplementation with algae oil each weekend for 5 weeks (equivalent to 750 mg of DHA and 375 mg EPA per day) | - Improvement in both low baseline O3I and high AA/EPA ratio with body mass-specific dose effects |
Lembke et al., 2014 [52] | 69 male and female college students | Randomized, placebo-controlled study | Supplementation with 2.7 g ω-3 PUFA/day for 30 days | - Less pain related to DOMS following heavy exercise at 72 and 96 h in subjects with a higher O3I reported - Lower serum levels of blood lactate in subjects with a high O3I - Reduction in CRP at 24 h in high O3I subjects |
Lust et al., 2023 [44] | 69 American football players | Randomized, double-blind, placebo-controlled, parallel-group study | Supplementation with 2, 4, or 6 g/day of DHA for 27 weeks | - Dose–response incorporation of DHA into RBC membranes up to 6 g/day - Achievement of >8% O3I in athletes in 8 weeks with 6 g/day of DHA supplementation |
MacArtney et al., 2014 [53] | 39 physically fit and healthy males | Double-blind, parallel-group study | Supplementation with 140 mg of EPA and 560 mg of DHA/day for 8 weeks | - Increase in O3I, reduction in mean heart rate during exercise, and improved heart rate recovery after supplementation |
Tomczyk et al., 2023 [54] | 26 amateur male long-distance runners | Randomized, parallel-group study | Supplementation with 2234 mg of EPA and 916 mg DHA/day for 12 weeks | - Increase in O3I and indicators of running performance, including running economy and peak oxygen uptake |
Zebrowska et al., 2021 [46] | 24 recreational marathon runners | Randomized, blind, placebo-controlled study | Supplementation with 852 mg EPA, 1602 mg DHA, and 12 mg and 30 µg of vitamin E and D/day for 3 weeks | - Increase in O3I and decrease in AA/EPA ratio after supplementation - Positive changes in lipid composition of erythrocytes, serum adipocytokines, and post-exercise proinflammatory cytokine levels |
3. ω-3 Index and Sports Injury Prevention
4. ω-3 Index and Sport Performance
4.1. ω-3 Index and Strength and Power
4.2. ω-3 Index and Endurance Performance
4.3. ω-3 Index and Exercise-Induced Fatigue
5. Conclusions
Author Contributions
Funding
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Medoro, A.; Buonsenso, A.; Centorbi, M.; Calcagno, G.; Scapagnini, G.; Fiorilli, G.; Davinelli, S. Omega-3 Index as a Sport Biomarker: Implications for Cardiovascular Health, Injury Prevention, and Athletic Performance. J. Funct. Morphol. Kinesiol. 2024, 9, 91. https://doi.org/10.3390/jfmk9020091
Medoro A, Buonsenso A, Centorbi M, Calcagno G, Scapagnini G, Fiorilli G, Davinelli S. Omega-3 Index as a Sport Biomarker: Implications for Cardiovascular Health, Injury Prevention, and Athletic Performance. Journal of Functional Morphology and Kinesiology. 2024; 9(2):91. https://doi.org/10.3390/jfmk9020091
Chicago/Turabian StyleMedoro, Alessandro, Andrea Buonsenso, Marco Centorbi, Giuseppe Calcagno, Giovanni Scapagnini, Giovanni Fiorilli, and Sergio Davinelli. 2024. "Omega-3 Index as a Sport Biomarker: Implications for Cardiovascular Health, Injury Prevention, and Athletic Performance" Journal of Functional Morphology and Kinesiology 9, no. 2: 91. https://doi.org/10.3390/jfmk9020091
APA StyleMedoro, A., Buonsenso, A., Centorbi, M., Calcagno, G., Scapagnini, G., Fiorilli, G., & Davinelli, S. (2024). Omega-3 Index as a Sport Biomarker: Implications for Cardiovascular Health, Injury Prevention, and Athletic Performance. Journal of Functional Morphology and Kinesiology, 9(2), 91. https://doi.org/10.3390/jfmk9020091