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Open AccessArticle

Design of a Thorium Metal Target for 225Ac Production at TRIUMF

1
Life Sciences Division, TRIUMF, Vancouver, BC V6T 2A3, Canada
2
Department of Physics and Astronomy, University of British Columbia, Vancouver, BC V6T 1Z1, Canada
3
Department of Radiology, University of British Columbia, Vancouver, BC V5Z 1M9, Canada
4
Department of Physics and Astronomy, University of Victoria, Victoria, BC V8W 2Y2, Canada
*
Author to whom correspondence should be addressed.
Instruments 2019, 3(1), 18; https://doi.org/10.3390/instruments3010018
Received: 26 December 2018 / Revised: 1 February 2019 / Accepted: 11 February 2019 / Published: 15 February 2019
(This article belongs to the Special Issue Instruments and Methods for Cyclotron Produced Radioisotopes)
With recent impressive clinical results of targeted alpha therapy using 225Ac, significant effort has been directed towards providing a reliable and sufficient supply of 225Ac to enable widespread using of 225Ac-radiopharmaceuticals. TRIUMF has begun production of 225Ac via spallation of thorium metal with 480 MeV protons. As part of this program, a new 225Ac-production target system capable of withstanding the power deposited by the proton beam was designed and its performance simulated over a range of potential operating parameters. Special attention was given to heat transfer and stresses within the target components. The target was successfully tested in two irradiations with a 72–73 µA proton beam for a duration of 36.5 h. The decay corrected activity at end of irradiation (average ± standard deviation) was (524 ± 21) MBq (14.2 mCi) and (86 ± 13) MBq (2.3 mCi) for 225Ac and 225Ra, respectively. These correspond to saturation yields of 72.5 MBq/µA for 225Ac and 17.6 MBq/µA for 225Ra. Longer irradiations and production scale-up are planned in the future. View Full-Text
Keywords: actinium-225; thorium; spallation; proton target; ANSYS; targeted alpha therapy actinium-225; thorium; spallation; proton target; ANSYS; targeted alpha therapy
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Robertson, A.K.; Lobbezoo, A.; Moskven, L.; Schaffer, P.; Hoehr, C. Design of a Thorium Metal Target for 225Ac Production at TRIUMF. Instruments 2019, 3, 18.

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