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Article

Transcriptome Analysis of Immune Response Against Edwardsiella tarda Infection in Spotted Sea Bass (Lateolabrax maculatus)

by
Zhaosheng Sun
1,2,†,
Xia Li
1,2,†,
Qingling Zhang
1,2,
Wei Wang
1,2,
Huan Wang
3,
Tingshuang Pan
3 and
Qian Gao
1,2,*
1
Key Laboratory of Exploration and Utilization of Aquatic Genetic Resources, Ministry of Education, Shanghai Ocean University, Shanghai 201306, China
2
National Demonstration Center for Experimental Fisheries Science Education, Shanghai Ocean University, Shanghai 201306, China
3
Institute of Fisheries Science, Anhui Academy of Agricultural Sciences, Hefei 230031, China
*
Author to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Fishes 2025, 10(4), 153; https://doi.org/10.3390/fishes10040153
Submission received: 10 February 2025 / Revised: 17 March 2025 / Accepted: 24 March 2025 / Published: 1 April 2025
(This article belongs to the Special Issue Interactions Between Fish and Pathogens in Aquaculture—2nd Edition)
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Abstract

Edwardsiella tarda is a gram-negative bacterium reported to be one of the most harmful pathogens in aquaculture. In this study, we conducted transcriptome profiling of the head kidney, liver, and spleen in spotted sea bass (Lateolabrax maculatus) infected with E. tarda. A total of 22,015 unigenes were detected by de novo assembly and annotated by comparison with the major databases (NR, GO, COG, KEGG, Swiss-Prot), with 21,065 (NR:95.68%), 11,320 (GO:51.42%), 20,464 (COG:92.95%), 21,295 (KEGG:96.73%), 18,791 (Swiss-Prot:82%). Subsequently, a substantial number of differentially expressed genes (DEGs) were identified (p-adjust < 0.05). In the head kidney, liver, and spleen, there were 1302 upregulated genes and 503 downregulated genes, 377 upregulated genes and 530 downregulated genes, and 1240 upregulated genes and 736 downregulated genes, respectively. Additionally, the expression levels of eight immune-related DEGs were validated by qRT-PCR, further verifying the reliability of the transcriptome data. To the best of our knowledge, this is the first analysis of the transcriptome profile of L. maculatus in response to E. tarda. These findings not only offer fundamental insights into the antibacterial immune mechanisms of spotted sea bass but also serve as a reference for formulating more effective fish disease management strategies.
Keywords: transcriptome analysis; Lateolabrax maculatus; Edwardsiella tarda; immune mechanism transcriptome analysis; Lateolabrax maculatus; Edwardsiella tarda; immune mechanism

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MDPI and ACS Style

Sun, Z.; Li, X.; Zhang, Q.; Wang, W.; Wang, H.; Pan, T.; Gao, Q. Transcriptome Analysis of Immune Response Against Edwardsiella tarda Infection in Spotted Sea Bass (Lateolabrax maculatus). Fishes 2025, 10, 153. https://doi.org/10.3390/fishes10040153

AMA Style

Sun Z, Li X, Zhang Q, Wang W, Wang H, Pan T, Gao Q. Transcriptome Analysis of Immune Response Against Edwardsiella tarda Infection in Spotted Sea Bass (Lateolabrax maculatus). Fishes. 2025; 10(4):153. https://doi.org/10.3390/fishes10040153

Chicago/Turabian Style

Sun, Zhaosheng, Xia Li, Qingling Zhang, Wei Wang, Huan Wang, Tingshuang Pan, and Qian Gao. 2025. "Transcriptome Analysis of Immune Response Against Edwardsiella tarda Infection in Spotted Sea Bass (Lateolabrax maculatus)" Fishes 10, no. 4: 153. https://doi.org/10.3390/fishes10040153

APA Style

Sun, Z., Li, X., Zhang, Q., Wang, W., Wang, H., Pan, T., & Gao, Q. (2025). Transcriptome Analysis of Immune Response Against Edwardsiella tarda Infection in Spotted Sea Bass (Lateolabrax maculatus). Fishes, 10(4), 153. https://doi.org/10.3390/fishes10040153

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