A Rare Case of Thymic Rosai-Dorfman Disease Mimicking Malignancy on 18F-FDG PET/CT

Jia, Tongtong; Zhang, Bin; Zhang, Xiaoyi; Xu, Xin; Sang, Shibiao; Deng, Shengming

doi:10.3390/tomography8060237

Open AccessCase Report

A Rare Case of Thymic Rosai-Dorfman Disease Mimicking Malignancy on ¹⁸F-FDG PET/CT

by

Tongtong Jia

^1,†,

Bin Zhang

^1,†,

Xiaoyi Zhang

^2,†,

Xin Xu

¹,

Shibiao Sang

^1,* and

Shengming Deng

^1,3,4,*

¹

Department of Nuclear Medicine, The First Affiliated Hospital of Soochow University, Suzhou 215006, China

²

Department of Nuclear Medicine, Changshu No. 2 People’s Hospital, Suzhou 215501, China

³

NHC Key Laboratory of Nuclear Technology Medical Transformation, Mianyang Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Mianyang 621000, China

⁴

State Key Laboratory of Radiation Medicine and Protection, Soochow University, Suzhou 215123, China

^*

Authors to whom correspondence should be addressed.

^†

These authors contributed equally to this work.

Tomography 2022, 8(6), 2839-2843; https://doi.org/10.3390/tomography8060237

Submission received: 17 September 2022 / Revised: 7 November 2022 / Accepted: 21 November 2022 / Published: 28 November 2022

(This article belongs to the Topic F-18 FDG PET/CT Imaging)

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Abstract

Background Rosai-Dorfman disease (RDD), the massive lymphadenopathy characterized by the proliferation of sinus histiocytosis, is a relatively idiopathic benign disease with unknown etiology. We reported a rare case of thymic RDD detected by ¹⁸F-FDG PET/CT. A 23-year-old man with right-sided chest pain underwent ¹⁸F-FDG PET/CT scan, showing increased ¹⁸F-FDG uptake in an anterior mediastinal mass corresponding to a thymic lesion at an enhanced CT scan. The patient was referred to surgery with the clinical suspicion of thymic malignancy. The histological examination and immunohistochemical results confirmed RDD. Conclusions This was the first case report of RDD isolated to the thymus and initially presented with chest pain. Moreover, there was no characteristic painless neck lymphadenopathy at any stage of the disease course. Thus, for young patients with thymus mass, RDD should be considered a rare but possible diagnosis.

Keywords: Rosai-Dorfman disease; sinus histiocytosis with massive lymphadenopathy; histiocytosis; ¹⁸F-FDG PET/CT

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MDPI and ACS Style

Jia, T.; Zhang, B.; Zhang, X.; Xu, X.; Sang, S.; Deng, S. A Rare Case of Thymic Rosai-Dorfman Disease Mimicking Malignancy on ¹⁸F-FDG PET/CT. Tomography 2022, 8, 2839-2843. https://doi.org/10.3390/tomography8060237

AMA Style

Jia T, Zhang B, Zhang X, Xu X, Sang S, Deng S. A Rare Case of Thymic Rosai-Dorfman Disease Mimicking Malignancy on ¹⁸F-FDG PET/CT. Tomography. 2022; 8(6):2839-2843. https://doi.org/10.3390/tomography8060237

Chicago/Turabian Style

Jia, Tongtong, Bin Zhang, Xiaoyi Zhang, Xin Xu, Shibiao Sang, and Shengming Deng. 2022. "A Rare Case of Thymic Rosai-Dorfman Disease Mimicking Malignancy on ¹⁸F-FDG PET/CT" Tomography 8, no. 6: 2839-2843. https://doi.org/10.3390/tomography8060237

APA Style

Jia, T., Zhang, B., Zhang, X., Xu, X., Sang, S., & Deng, S. (2022). A Rare Case of Thymic Rosai-Dorfman Disease Mimicking Malignancy on ¹⁸F-FDG PET/CT. Tomography, 8(6), 2839-2843. https://doi.org/10.3390/tomography8060237

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A Rare Case of Thymic Rosai-Dorfman Disease Mimicking Malignancy on ¹⁸F-FDG PET/CT

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