Prostate Cancer Biochemical Recurrence Resulted Negative on [68Ga]Ga-PSMA-11 but Positive on [18F]Fluoromethylcholine PET/CT
Abstract
:1. Introduction
2. Case
3. Discussion
4. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
- Gandaglia, G.; Leni, R.; Bray, F.; Fleshner, N.; Freedland, S.J.; Kibel, A.; Stattin, P.; Van Poppel, H.; La Vecchia, C. Epidemiology and Prevention of Prostate Cancer. Eur. Urol. Oncol. 2021, 4, 877–892. [Google Scholar] [CrossRef] [PubMed]
- Mottet, N.; van den Bergh, R.C.N.; Briers, E.; Van den Broeck, T.; Cumberbatch, M.G.; De Santis, M.; Fanti, S.; Fossati, N.; Gandaglia, G.; Gillessen, S.; et al. EAU-EANM-ESTRO-ESUR-SIOG Guidelines on Prostate Cancer-2020 Update. Part 1: Screening, Diagnosis, and Local Treatment with Curative Intent. Eur. Urol. 2021, 79, 243–262. [Google Scholar] [CrossRef]
- Morigi, J.J.; Stricker, P.D.; van Leeuwen, P.J.; Tang, R.; Ho, B.; Nguyen, Q.; Hruby, G.; Fogarty, G.; Jagavkar, R.; Kneebone, A.; et al. Prospective Comparison of 18F-Fluoromethylcholine Versus 68Ga-PSMA PET/CT in Prostate Cancer Patients Who Have Rising PSA After Curative Treatment and Are Being Considered for Targeted Therapy. J. Nucl. Med. 2015, 56, 1185–1190. [Google Scholar] [CrossRef]
- Alongi, P.; Quartuccio, N.; Arnone, A.; Kokomani, A.; Allocca, M.; Nappi, A.G.; Santo, G.; Mantarro, C.; Laudicella, R. Brain PET/CT using prostate cancer radiopharmaceutical agents in the evaluation of gliomas. Clin. Transl. Imaging 2020, 8, 433–448. [Google Scholar] [CrossRef]
- Cornford, P.; van den Bergh, R.C.N.; Briers, E.; Van den Broeck, T.; Cumberbatch, M.G.; De Santis, M.; Fanti, S.; Fossati, N.; Gandaglia, G.; Gillessen, S.; et al. EAU-EANM-ESTRO-ESUR-SIOG Guidelines on Prostate Cancer. Part II-2020 Update: Treatment of Relapsing and Metastatic Prostate Cancer. Eur. Urol. 2021, 79, 263–282. [Google Scholar] [CrossRef]
- Rosar, F.; Ribbat, K.; Ries, M.; Linxweiler, J.; Bartholomä, M.; Maus, S.; Schreckenberger, M.; Ezziddin, S.; Khreish, F. Neuron-specific enolase has potential value as a biomarker for [18F]FDG/[68Ga]Ga-PSMA-11 PET mismatch findings in advanced mCRPC patients. EJNMMI Res. 2020, 10, 52. [Google Scholar] [CrossRef] [PubMed]
- Rüschoff, J.H.; Ferraro, D.A.; Muehlematter, U.J.; Laudicella, R.; Hermanns, T.; Rodewald, A.K.; Moch, H.; Eberli, D.; Burger, I.A.; Rupp, N.J. What’s behind 68Ga-PSMA-11 uptake in primary prostate cancer PET? Investigation of histopathological parameters and immunohistochemical PSMA expression patterns. Eur. J. Nucl. Med. Mol. Imaging 2021, 48, 4042–4053. [Google Scholar] [CrossRef]
- Laudicella, R.; Rüschoff, J.H.; Ferraro, D.A.; Brada, M.D.; Hausmann, D.; Mebert, I.; Maurer, A.; Hermanns, T.; Eberli, D.; Rupp, N.J.; et al. Infiltrative growth pattern of prostate cancer is associated with lower uptake on PSMA PET and reduced diffusion restriction on mpMRI. Eur. J. Nucl. Med. Mol. Imaging 2022, 49, 3917–3928. [Google Scholar] [CrossRef] [PubMed]
- Bauckneht, M.; Bertagna, F.; Donegani, M.I.; Durmo, R.; Miceli, A.; De Biasi, V.; Laudicella, R.; Fornarini, G.; Berruti, A.; Baldari, S.; et al. The prognostic power of 18F-FDG PET/CT extends to estimating systemic treatment response duration in metastatic castration-resistant prostate cancer (mCRPC) patients. Prostate Cancer Prostatic. Dis. 2021, 24, 1198–1207. [Google Scholar] [CrossRef] [PubMed]
- Laudicella, R.; Albano, D.; Alongi, P.; Argiroffi, G.; Bauckneht, M.; Baldari, S.; Bertagna, F.; Boero, M.; Vincentis, G.; Sole, A.D.; et al. 18F-Facbc in Prostate Cancer: A Systematic Review and Meta-Analysis. Cancers 2019, 11, 1348. [Google Scholar] [CrossRef] [Green Version]
- Baratto, L.; Duan, H.; Laudicella, R.; Toriihara, A.; Hatami, N.; Ferri, V.; Iagaru, A. Physiological 68Ga-RM2 uptake in patients with biochemically recurrent prostate cancer: An atlas of semi-quantitative measurements. Eur. J. Nucl. Med. Mol. Imaging 2020, 47, 115–122. [Google Scholar] [CrossRef]
- Kesch, C.; Yirga, L.; Dendl, K.; Handke, A.; Darr, C.; Krafft, U.; Radtke, J.P.; Tschirdewahn, S.; Szarvas, T.; Fazli, L.; et al. High fibroblast-activation-protein expression in castration-resistant prostate cancer supports the use of FAPI-molecular theranostics. Eur. J. Nucl. Med. Mol. Imaging 2021, 49, 385–389. [Google Scholar] [CrossRef]
- Afshar-Oromieh, A.; Zechmann, C.M.; Malcher, A.; Eder, M.; Eisenhut, M.; Linhart, H.G.; Holland-Letz, T.; Hadaschik, B.A.; Giesel, F.L.; Debus, J.; et al. Comparison of PET imaging with a 68Ga-labelled PSMA ligand and 18F-choline-based PET/CT for the diagnosis of recurrent prostate cancer. Eur. J. Nucl. Med. Mol. Imaging 2014, 41, 11–20. [Google Scholar] [CrossRef]
- Schwenck, J.; Rempp, H.; Reischl, G.; Kruck, S.; Stenzl, A.; Nikolaou, K.; Pfannenberg, C.; la Fougère, C. Comparison of 68Ga-labelled PSMA-11 and 11C-choline in the detection of prostate cancer metastases by PET/CT. Eur. J. Nucl. Med. Mol. Imaging 2017, 44, 92–101. [Google Scholar] [CrossRef] [PubMed]
- Emmett, L.; Metser, U.; Bauman, G.; Hicks, R.J.; Weickhardt, A.; Davis, I.D.; Punwani, S.; Pond, G.; Chua, S.; Ho, B.; et al. Prospective, Multisite, International Comparison of 18F-Fluoromethylcholine PET/CT, Multiparametric MRI, and 68Ga-HBED-CC PSMA-11 PET/CT in Men with High-Risk Features and Biochemical Failure After Radical Prostatectomy: Clinical Performance and Patient Outcomes. J. Nucl. Med. 2019, 60, 794–800. [Google Scholar]
- Barbaud, M.; Frindel, M.; Ferrer, L.; Le Thiec, M.; Rusu, D.; Rauscher, A.; Maucherat, B.; Baumgartner, P.; Fleury, V.; Colombié, M.; et al. 68Ga-PSMA-11 PET-CT study in prostate cancer patients with biochemical recurrence and non-contributive 18F-Choline PET-CT: Impact on therapeutic decision-making and biomarker changes. Prostate 2019, 79, 454–461. [Google Scholar] [CrossRef]
- Witkowska-Patena, E.; Giżewska, A.; Dziuk, M.; Miśko, J.; Budzyńska, A.; Walęcka-Mazur, A. Head-to-Head Comparison of 18F-Prostate-Specific Membrane Antigen-1007 and 18F-Fluorocholine PET/CT in Biochemically Relapsed Prostate Cancer. Clin. Nucl. Med. 2019, 44, e629–e633. [Google Scholar] [CrossRef] [PubMed]
- Mazzola, R.; Francolini, G.; Triggiani, L.; Napoli, G.; Cuccia, F.; Nicosia, L.; Livi, L.; Magrini, S.M.; Salgarello, M.; Alongi, F. Metastasis-directed Therapy (SBRT) Guided by PET-CT 18F-CHOLINE Versus PET-CT 68Ga-PSMA in Castration-sensitive Oligorecurrent Prostate Cancer: A Comparative Analysis of Effectiveness. Clin. Genitourin. Cancer 2021, 19, 230–236. [Google Scholar] [CrossRef] [PubMed]
- Yadav, S.S.; Stockert, J.A.; Hackert, V.; Yadav, K.K.; Tewari, A.K. Intratumor heterogeneity in prostate cancer. Urol. Oncol. 2018, 36, 349–360. [Google Scholar] [CrossRef] [PubMed]
- Alberts, I.; Sachpekidis, C.; Fech, V.; Rominger, A.; Afshar-Oromieh, A. PSMA-negative prostate cancer and the continued value of choline-PET/CT. Nuklearmedizin 2020, 59, 33–34. [Google Scholar] [CrossRef]
01/2015 | 06/2015 | 12/2015 | 01/2016 | 01/2020 | 01/2021 | 03/2021 | 05/2021 | 06/2021 |
---|---|---|---|---|---|---|---|---|
RPE + pelvic RT | 0.25 ng/mL | 0.5 ng/mL | Estramustin ephosphate | 0.01 ng/mL | 1.9 ng/mL | 3.05 ng/mL | Extended bilateral common iliac limphadenectomy | <0.01 ng/mL |
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Laudicella, R.; La Torre, F.; Davì, V.; Crocè, L.; Aricò, D.; Leonardi, G.; Russo, S.; Minutoli, F.; Burger, I.A.; Baldari, S. Prostate Cancer Biochemical Recurrence Resulted Negative on [68Ga]Ga-PSMA-11 but Positive on [18F]Fluoromethylcholine PET/CT. Tomography 2022, 8, 2471-2474. https://doi.org/10.3390/tomography8050205
Laudicella R, La Torre F, Davì V, Crocè L, Aricò D, Leonardi G, Russo S, Minutoli F, Burger IA, Baldari S. Prostate Cancer Biochemical Recurrence Resulted Negative on [68Ga]Ga-PSMA-11 but Positive on [18F]Fluoromethylcholine PET/CT. Tomography. 2022; 8(5):2471-2474. https://doi.org/10.3390/tomography8050205
Chicago/Turabian StyleLaudicella, Riccardo, Flavia La Torre, Valerio Davì, Ludovica Crocè, Demetrio Aricò, Giuseppe Leonardi, Simona Russo, Fabio Minutoli, Irene A. Burger, and Sergio Baldari. 2022. "Prostate Cancer Biochemical Recurrence Resulted Negative on [68Ga]Ga-PSMA-11 but Positive on [18F]Fluoromethylcholine PET/CT" Tomography 8, no. 5: 2471-2474. https://doi.org/10.3390/tomography8050205