Next Article in Journal
The Infraoptic or Infrachiasmatic Course of the Anterior Cerebral Artery Emerging an Elongated Internal Carotid Artery
Previous Article in Journal
Statistical Interior Tomography via L1 Norm Dictionary Learning without Assuming an Object Support
Previous Article in Special Issue
Dynamic Contrast Enhanced Study in Multiparametric Examination of the Prostate—Can We Make Better Use of It?
 
 
Article

Cytoreductive Surgical Treatment of Pleural Mesothelioma in a Porcine Model Using Magnetic-Resonance-Guided Focused Ultrasound Surgery (MRgFUS) and Radiofrequency Ablation (RFA)

1
Faculdade de Ciencias, Universidade de Lisboa, 1749-016 Lisboa, Portugal
2
Focused Ultrasound Foundation, Charlottesville, VA 22903, USA
3
Department of Radiology & Medical Imaging, University of Virginia, Charlottesville, VA 22903, USA
*
Author to whom correspondence should be addressed.
Academic Editors: David A. Hormuth and Chengyue Wu
Tomography 2022, 8(5), 2232-2242; https://doi.org/10.3390/tomography8050187
Received: 18 July 2022 / Revised: 25 August 2022 / Accepted: 1 September 2022 / Published: 3 September 2022
(This article belongs to the Special Issue New Advances in Medical Imaging and Applied Radiology in Cancers)
A combination of surgery and chemotherapy is the most effective treatment available for Malignant Pleural Mesothelioma (MPM). However, both cause significant collateral damage and cannot eliminate residual microscopic disease. This investigation aimed to compare and determine the feasibility of utilizing Radiofrequency Ablation (RFA) and Magnetic-Resonance-guided Focused Ultrasound Surgery (MRgFUS) as alternative treatments for MPM. A large animal tumor model was developed in 13 Yorkshire female pigs using the MSTO211H cell line. Two pigs were initially used to determine the cyclosporine dose required for immunosuppression and tumor development. Subsequently, 11 other pigs underwent tumor development. Of these 11, 2 died during cell inoculation. Small tumor masses and adhesions were present in the other 9, indicating mesothelioma development. Five pigs then received RFA treatment, and 4 pigs received MRgFUS treatment. Tumor model development and effect of the two treatments were examined using MRI and by necropsy. RFA and MRgFUS both successfully ablated approximately the same sized area in the same treatment time. This study demonstrates that RFA and MRgFUS are feasible for tumor debulking, and while MRgFUS requires more pretreatment planning compared to RFA, MRgFUS is a completely noninvasive procedure. View Full-Text
Keywords: high-intensity focused ultrasound; radiofrequency ablation; magnetic resonance imaging; mesothelioma high-intensity focused ultrasound; radiofrequency ablation; magnetic resonance imaging; mesothelioma
Show Figures

Graphical abstract

MDPI and ACS Style

Costa, M.; Fernandes, C.; Eames, M.; Hananel, A.; Mugler, J.P., III; Huaromo, J.; Yang, J.B.; Mata, J. Cytoreductive Surgical Treatment of Pleural Mesothelioma in a Porcine Model Using Magnetic-Resonance-Guided Focused Ultrasound Surgery (MRgFUS) and Radiofrequency Ablation (RFA). Tomography 2022, 8, 2232-2242. https://doi.org/10.3390/tomography8050187

AMA Style

Costa M, Fernandes C, Eames M, Hananel A, Mugler JP III, Huaromo J, Yang JB, Mata J. Cytoreductive Surgical Treatment of Pleural Mesothelioma in a Porcine Model Using Magnetic-Resonance-Guided Focused Ultrasound Surgery (MRgFUS) and Radiofrequency Ablation (RFA). Tomography. 2022; 8(5):2232-2242. https://doi.org/10.3390/tomography8050187

Chicago/Turabian Style

Costa, Marcia, Carolina Fernandes, Matt Eames, Arik Hananel, John P. Mugler III, Jhosep Huaromo, Jack B. Yang, and Jaime Mata. 2022. "Cytoreductive Surgical Treatment of Pleural Mesothelioma in a Porcine Model Using Magnetic-Resonance-Guided Focused Ultrasound Surgery (MRgFUS) and Radiofrequency Ablation (RFA)" Tomography 8, no. 5: 2232-2242. https://doi.org/10.3390/tomography8050187

Find Other Styles

Article Access Map by Country/Region

1
Back to TopTop