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Tomography
Volume 5
Issue 4
10.18383/j.tom.2019.00016
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Article

Ex Vivo Human Placenta Perfusion, Metabolic and Functional Imaging for Obstetric Research—A Feasibility Study

by
Katrine Elbæk Madsen
1,2,
Christian Østergaard Mariager
1,
Christina S. Duvald
2,
Esben Søvsø Szocska Hansen
1,
Lotte Bonde Bertelsen
1,
Michael Pedersen
2,
Lars Henning Pedersen
3,
Niels Uldbjerg
3 and
Christoffer Laustsen
1,*
1
Department of Clinical Medicine, MR-Research Centre, Aarhus University, Aarhus, Denmark
2
Department of Clinical Medicine, Comparative Medicine Laboratory, Aarhus University, Aarhus, Denmark
3
Department of Gynaecology and Obstetrics, Aarhus University Hospital and Department of Clinical Medicine, Aarhus University, Aarhus, Denmark
*
Author to whom correspondence should be addressed.
Tomography 2019, 5(4), 333-338; https://doi.org/10.18383/j.tom.2019.00016
Submission received: 9 September 2019 / Revised: 9 October 2019 / Accepted: 8 November 2019 / Published: 1 December 2019
Versions Notes

Abstract

Placenta metabolism is closely linked to pregnancy outcome, and few modalities are currently available for studying the human placenta. Here, we aimed to investigate a novel ex vivo human placenta perfusion system for metabolic imaging using hyperpolarized [1-13C]pyruvate. The metabolic effects of 3 different human placentas were investigated using functional and metabolic magnetic resonance imaging. The placenta glucose metabolism and hemodynamics were characterized with hyperpolarized [1-13C]pyruvate magnetic resonance imaging and by dynamic contrast-enhanced (DCE) imaging. Hyperpolarized [1-13C]pyruvate showed a decrease in the 13C-lactate/13C-pyruvate ratio from the highest to the lowest metabolic active placenta. The metabolic profile was complemented by a more homogenous distributed hemodynamic response, with a longer mean transit time and higher blood volume. This study shows different placenta metabolic and hemodynamic features associated with the placenta functional status using hyperpolarized magnetic resonance ex vivo. This study supports further studies using ex vivo metabolic imaging of the placenta alterations associated with pregnancy complications.
Keywords: Placenta; metabolism; hyperpolarization; 13C; pyruvate; MRI Placenta; metabolism; hyperpolarization; 13C; pyruvate; MRI

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MDPI and ACS Style

Madsen, K.E.; Mariager, C.Ø.; Duvald, C.S.; Hansen, E.S.S.; Bertelsen, L.B.; Pedersen, M.; Pedersen, L.H.; Uldbjerg, N.; Laustsen, C. Ex Vivo Human Placenta Perfusion, Metabolic and Functional Imaging for Obstetric Research—A Feasibility Study. Tomography 2019, 5, 333-338. https://doi.org/10.18383/j.tom.2019.00016

AMA Style

Madsen KE, Mariager CØ, Duvald CS, Hansen ESS, Bertelsen LB, Pedersen M, Pedersen LH, Uldbjerg N, Laustsen C. Ex Vivo Human Placenta Perfusion, Metabolic and Functional Imaging for Obstetric Research—A Feasibility Study. Tomography. 2019; 5(4):333-338. https://doi.org/10.18383/j.tom.2019.00016

Chicago/Turabian Style

Madsen, Katrine Elbæk, Christian Østergaard Mariager, Christina S. Duvald, Esben Søvsø Szocska Hansen, Lotte Bonde Bertelsen, Michael Pedersen, Lars Henning Pedersen, Niels Uldbjerg, and Christoffer Laustsen. 2019. "Ex Vivo Human Placenta Perfusion, Metabolic and Functional Imaging for Obstetric Research—A Feasibility Study" Tomography 5, no. 4: 333-338. https://doi.org/10.18383/j.tom.2019.00016

APA Style

Madsen, K. E., Mariager, C. Ø., Duvald, C. S., Hansen, E. S. S., Bertelsen, L. B., Pedersen, M., Pedersen, L. H., Uldbjerg, N., & Laustsen, C. (2019). Ex Vivo Human Placenta Perfusion, Metabolic and Functional Imaging for Obstetric Research—A Feasibility Study. Tomography, 5(4), 333-338. https://doi.org/10.18383/j.tom.2019.00016

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