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10.18383/j.tom.2019.00017
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Article

Defining Characteristics of Nodal Disease on PET/CT Scans in Patients With HIV-Positive and -Negative Locally Advanced Cervical Cancer in South Africa

by
Carrie Anne Minnaar
1,
Ans Baeyens
1,2,*,
Olusegun Akinwale Ayeni
3,
Jeffrey Allan Kotzen
4 and
Mboyo-Di-Tamba Vangu
5
1
Division of Radiobiology, Department of Radiation Sciences, University of the Witwatersrand, Johannesburg, South Africa
2
Division of Radiobiology, Department of Human Structure and Repair, Ghent University, Ghent, Belgium
3
Department of Nuclear Medicine, Charlotte Maxeke Johannesburg Academic Hospital, Johannesburg, South Africa
4
Department of Radiation Oncology, Wits Donald Gordon Medical Centre, Johannesburg, South Africa
5
Department of Nuclear Medicine, Department of Radiation Sciences, University of the Witwatersrand, Johannesburg, South Africa
*
Author to whom correspondence should be addressed.
Tomography 2019, 5(4), 339-345; https://doi.org/10.18383/j.tom.2019.00017
Submission received: 12 September 2019 / Revised: 11 October 2019 / Accepted: 10 November 2019 / Published: 1 December 2019
Versions Notes

Abstract

Literature reports increased FDG nodal uptake in HIV-positive patients. Our aim is to identify differences in presentation and characteristics of FDG-avid lymph nodes between HIV-positive and HIV-negative locally advanced cervical cancer (LACC) patients in our clinical setting. We evaluated 250 pre-treatment 18F-FDG PET/CT imaging studies from women screened for a phase III randomised controlled trial investigating modulated electro-hyperthermia as a radiosensitiser (Ethics approval: M120477). The number of nodes; size; maximum standardised uptake value (SUVmax); symmetry; and relationship between nodal size and SUVmax uptake, were assessed by region and by HIV status. In total, 1314 nodes with a SUVmax ≥ 2.5 were visualised. Of 128(51%) HIV-positive participants, 82% were on antiretroviral therapy (ART) and 10 had a CD4 count four nodes visualised in the neck, symmetrical inguinal lymph nodes, increased rates of supraclavicular node visualisation; FDG-avid axillary nodes were more common, but not exclusive, in HIV-positive participants. 18F-FDG PET/CT is a reliable staging method for LACC in HIV-positive patients who are not in acute stages of HIV infection, have a CD4 count >200 cells/µL, and/or are on ART and there is a potential risk of underestimating metastatic spread by attributing increased nodal metabolic activity to HIV infection in these patients.
Keywords: 18F-FDG PET/CT; HIV; locally advanced cervical cancer; lymph nodes; disease pattern 18F-FDG PET/CT; HIV; locally advanced cervical cancer; lymph nodes; disease pattern

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MDPI and ACS Style

Minnaar, C.A.; Baeyens, A.; Ayeni, O.A.; Kotzen, J.A.; Vangu, M.-D.-T. Defining Characteristics of Nodal Disease on PET/CT Scans in Patients With HIV-Positive and -Negative Locally Advanced Cervical Cancer in South Africa. Tomography 2019, 5, 339-345. https://doi.org/10.18383/j.tom.2019.00017

AMA Style

Minnaar CA, Baeyens A, Ayeni OA, Kotzen JA, Vangu M-D-T. Defining Characteristics of Nodal Disease on PET/CT Scans in Patients With HIV-Positive and -Negative Locally Advanced Cervical Cancer in South Africa. Tomography. 2019; 5(4):339-345. https://doi.org/10.18383/j.tom.2019.00017

Chicago/Turabian Style

Minnaar, Carrie Anne, Ans Baeyens, Olusegun Akinwale Ayeni, Jeffrey Allan Kotzen, and Mboyo-Di-Tamba Vangu. 2019. "Defining Characteristics of Nodal Disease on PET/CT Scans in Patients With HIV-Positive and -Negative Locally Advanced Cervical Cancer in South Africa" Tomography 5, no. 4: 339-345. https://doi.org/10.18383/j.tom.2019.00017

APA Style

Minnaar, C. A., Baeyens, A., Ayeni, O. A., Kotzen, J. A., & Vangu, M. -D. -T. (2019). Defining Characteristics of Nodal Disease on PET/CT Scans in Patients With HIV-Positive and -Negative Locally Advanced Cervical Cancer in South Africa. Tomography, 5(4), 339-345. https://doi.org/10.18383/j.tom.2019.00017

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