Quantitative Magnetization Transfer Imaging of the Breast at 3.0 T: Reproducibility in Healthy Volunteers

Arlinghaus, Lori R.; Dortch, Richard D.; Whisenant, Jennifer G.; Kang, Hakmook; Abramson, Richard G.; Yankeelov, Thomas E.

doi:10.18383/j.tom.2016.00142

Open AccessArticle

Quantitative Magnetization Transfer Imaging of the Breast at 3.0 T: Reproducibility in Healthy Volunteers

by

Lori R. Arlinghaus

^1,*,

Richard D. Dortch

^1,2,3,

Jennifer G. Whisenant

⁴,

Hakmook Kang

^5,6,

Richard G. Abramson

^1,2,4 and

Thomas E. Yankeelov

^7,8,9,10

¹

Vanderbilt University Institute of Imaging Science, Vanderbilt University Medical Center, Nashville, TN, USA

²

Department of Radiology and Radiological Sciences, VanderbiltUniversity Medical Center, Nashville, TN, USA

³

Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, USA

⁴

Vanderbilt-Ingram Cancer Center,Vanderbilt University Medical Center, Nashville, TN, USA

⁵

Department of Biostatistics, Vanderbilt University Medical Center, Nashville, TN, USA

⁶

Center for QuantitativeSciences, Vanderbilt University Medical Center, Nashville, TN, USA

⁷

Department of Biomedical Engineering, The University of Texas at Austin, Austin, TX, USA

⁸

Department ofInternal Medicine, The University of Texas at Austin, Austin, TX, USA

⁹

Institute for Computational and Engineering Sciences, The University of Texas at Austin, Austin, TX, USA

¹⁰

Livestrong Cancer Institutes, The University of Texas at Austin, Austin, TX, USA

^*

Author to whom correspondence should be addressed.

Tomography 2016, 2(4), 260-266; https://doi.org/10.18383/j.tom.2016.00142

Submission received: 2 September 2016 / Revised: 4 October 2016 / Accepted: 6 November 2016 / Published: 1 December 2016

Download Versions Notes

Abstract

Quantitative magnetization transfer magnetic resonance imaging provides a means for indirectly detecting changes in the macromolecular content of tissue noninvasively. A potential application is the diagnosis and assessment of treatment response in breast cancer; however, before quantitative magnetization transfer imaging can be reliably used in such settings, the technique's reproducibility in healthy breast tissue must be established. Thus, this study aims to establish the reproducibility of the measurement of the macromolecular-to-free water proton pool size ratio (PSR) in healthy fibroglandular (FG) breast tissue. Thirteen women with no history of breast disease were scanned twice within a single scanning session, with repositioning between scans. Eleven women had appreciable FG tissue for test–retest measurements. Mean PSR values for the FG tissue ranged from 9.5% to 16.7%. The absolute value of the difference between 2 mean PSR measurements for each volunteer ranged from 0.1% to 2.1%. The 95% confidence interval for the mean difference was ±0.75%, and the repeatability value was 2.39%. These results indicate that the expected measurement variability would be ±0.75% for a cohort of a similar size and would be ±2.39% for an individual, suggesting that future studies of change in PSR in patients with breast cancer are feasible.

Keywords: quantitative MR; breast cancer; pool size ratio; test–retest

Share and Cite

MDPI and ACS Style

Arlinghaus, L.R.; Dortch, R.D.; Whisenant, J.G.; Kang, H.; Abramson, R.G.; Yankeelov, T.E. Quantitative Magnetization Transfer Imaging of the Breast at 3.0 T: Reproducibility in Healthy Volunteers. Tomography 2016, 2, 260-266. https://doi.org/10.18383/j.tom.2016.00142

AMA Style

Arlinghaus LR, Dortch RD, Whisenant JG, Kang H, Abramson RG, Yankeelov TE. Quantitative Magnetization Transfer Imaging of the Breast at 3.0 T: Reproducibility in Healthy Volunteers. Tomography. 2016; 2(4):260-266. https://doi.org/10.18383/j.tom.2016.00142

Chicago/Turabian Style

Arlinghaus, Lori R., Richard D. Dortch, Jennifer G. Whisenant, Hakmook Kang, Richard G. Abramson, and Thomas E. Yankeelov. 2016. "Quantitative Magnetization Transfer Imaging of the Breast at 3.0 T: Reproducibility in Healthy Volunteers" Tomography 2, no. 4: 260-266. https://doi.org/10.18383/j.tom.2016.00142

APA Style

Arlinghaus, L. R., Dortch, R. D., Whisenant, J. G., Kang, H., Abramson, R. G., & Yankeelov, T. E. (2016). Quantitative Magnetization Transfer Imaging of the Breast at 3.0 T: Reproducibility in Healthy Volunteers. Tomography, 2(4), 260-266. https://doi.org/10.18383/j.tom.2016.00142

Article Menu

Quantitative Magnetization Transfer Imaging of the Breast at 3.0 T: Reproducibility in Healthy Volunteers

Abstract

Share and Cite

Article Metrics

Article Access Statistics

Further Information

Guidelines

MDPI Initiatives

Follow MDPI