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Controlling the Antimicrobial Action of Surface Modified Magnesium Hydroxide Nanoparticles

1
Department of Chemistry and Biochemistry, University of Hull, Hull HU67RX, UK
2
Department of Chemistry, College of Science, University of Babylon, Hilla, Iraq
*
Author to whom correspondence should be addressed.
Biomimetics 2019, 4(2), 41; https://doi.org/10.3390/biomimetics4020041
Received: 17 February 2019 / Revised: 12 June 2019 / Accepted: 20 June 2019 / Published: 25 June 2019
(This article belongs to the Special Issue Selected Papers from Bioinspired Materials 2018)
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Abstract

Magnesium hydroxide nanoparticles (Mg(OH)2NPs) have recently attracted significant attention due to their wide applications as environmentally friendly antimicrobial nanomaterials, with potentially low toxicity and low fabrication cost. Here, we describe the synthesis and characterisation of a range of surface modified Mg(OH)2NPs, including particle size distribution, crystallite size, zeta potential, isoelectric point, X-ray diffraction (XRD), dynamic light scattering (DLS), scanning electron microscopy (SEM), thermogravimetric analysis (TGA), energy dispersive X-ray analysis (EDX), Fourier transform infrared spectroscopy (FTIR), and transmission electron microscopy (TEM). We explored the antimicrobial activity of the modified Mg(OH)2NPs on the microalgae (C. reinhardtii), yeast (S. cerevisiae) and Escherichia coli (E. coli). The viability of these cells was evaluated for various concentrations and exposure times with Mg(OH)2NPs. It was discovered that the antimicrobial activity of the uncoated Mg(OH)2NPs on the viability of C. reinhardtii occurred at considerably lower particle concentrations than for S. cerevisiae and E. coli. Our results indicate that the antimicrobial activity of polyelectrolyte-coated Mg(OH)2NPs alternates with their surface charge. The anionic nanoparticles (Mg(OH)2NPs/PSS) have much lower antibacterial activity than the cationic ones (Mg(OH)2NPs/PSS/PAH and uncoated Mg(OH)2NPs). These findings could be explained by the lower adhesion of the Mg(OH)2NPs/PSS to the cell wall, because of electrostatic repulsion and the enhanced particle-cell adhesion due to electrostatic attraction in the case of cationic Mg(OH)2NPs. The results can be potentially applied to control the cytotoxicity and the antimicrobial activity of other inorganic nanoparticles. View Full-Text
Keywords: Mg(OH)2NPs; magnesium hydroxide; polyelectrolytes; poly (styrene sulfonate); poly (allyl amine) hydrochloride; antimicrobial nanoparticles; algae; yeast; bacteria; C. reinhardtii; S.cerevisiae; E. coli Mg(OH)2NPs; magnesium hydroxide; polyelectrolytes; poly (styrene sulfonate); poly (allyl amine) hydrochloride; antimicrobial nanoparticles; algae; yeast; bacteria; C. reinhardtii; S.cerevisiae; E. coli
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Halbus, A.F.; Horozov, T.S.; Paunov, V.N. Controlling the Antimicrobial Action of Surface Modified Magnesium Hydroxide Nanoparticles. Biomimetics 2019, 4, 41.

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