Next Article in Journal
Cellulose Nanofiber-Reinforced Chitosan Hydrogel Composites for Intervertebral Disc Tissue Repair
Next Article in Special Issue
Controlling the Antimicrobial Action of Surface Modified Magnesium Hydroxide Nanoparticles
Previous Article in Journal / Special Issue
Effects of Capsaicin on Biomimetic Membranes
Open AccessArticle

Synthesis of Optimized Molecularly Imprinted Polymers for the Isolation and Detection of Antidepressants via HPLC

1
Manchester Metropolitan University, Faculty of Science and Engineering, Division of Chemistry and Environmental Science, Manchester M1 5GD, UK
2
Departamento de Engenharia Química, Escola Politécnica, Universidade de São Paulo, Avenida Prof. Luciano Gualberto, Travessa 3, 380, CEP05508-900 São Paulo, Brazil
3
Department of Chemical Engineering, Centre for Advanced Separations Engineering, University of Bath, Claverton Down, Bath BA2 7AY, UK
*
Author to whom correspondence should be addressed.
This article is an extended version of our paper presented at the Bioinspired Materials 2018 conference; paper No. P3.
Biomimetics 2019, 4(1), 18; https://doi.org/10.3390/biomimetics4010018
Received: 19 December 2018 / Revised: 4 February 2019 / Accepted: 14 February 2019 / Published: 20 February 2019
(This article belongs to the Special Issue Selected Papers from Bioinspired Materials 2018)
Antidepressants such as amitryptiline and fluoxetine are on the list of modern essential medicines of the World Health Organization. However, there are growing concerns regarding the ecological impact of these pharmaceuticals, leading to a great need to improve current wastewater treatment procedures. In this contribution, we will report on the use of molecularly imprinted polymers (MIPs) for the extraction of antidepressants in water samples. MIPs were developed for fluoxetine and duloxetine, antidepressants belonging to the class of selective serotonin reuptake inhibitors (SSRIs). The binding capacity of these microparticles was evaluated using ultraviolet–visible (UV–Vis) spectroscopy. A new high-performance liquid chromatography (HPLC) procedure coupled to UV detection was developed, which enabled the study of mixtures of fluoxetine and duloxetine with other nitrogen-containing compounds. These results indicate that it is possible to selectively extract SSRIs from complex samples. Therefore, these versatile polymers are a promising analytical tool for the clean-up of water samples, which will benefit aquatic life and reduce the ecological impact of pharmaceuticals. View Full-Text
Keywords: molecularly imprinted polymers; fluoxetine; selective serotonin reuptake inhibitors (SSRIs); optical batch rebinding; high-performance liquid chromatography molecularly imprinted polymers; fluoxetine; selective serotonin reuptake inhibitors (SSRIs); optical batch rebinding; high-performance liquid chromatography
Show Figures

Figure 1

MDPI and ACS Style

Hudson, A.D.; Solà, R.; Ueta, J.T.; Battell, W.; Jamieson, O.; Dunbar, T.; Maciá, B.; Peeters, M. Synthesis of Optimized Molecularly Imprinted Polymers for the Isolation and Detection of Antidepressants via HPLC. Biomimetics 2019, 4, 18.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop