Next Article in Journal
Effect of the Time of Salivary Contamination during Light Curing on Degree of Conversion and Microhardness of a Restorative Composite Resin
Next Article in Special Issue
Reprogramming Cells for Synergistic Combination Therapy with Nanotherapeutics against Uveal Melanoma
Previous Article in Journal
On the Ability of Low Molecular Weight Chitosan Enzymatically Depolymerized to Produce and Stabilize Silver Nanoparticles
Previous Article in Special Issue
Alterations in Cellular Processes Involving Vesicular Trafficking and Implications in Drug Delivery

Biosafety of Mesoporous Silica Nanoparticles

Institute of Chemistry and Biology of Membranes and Nano-objects (CBMN) UMR-5248, CNRS, University of Bordeaux, INP, Allée Geoffroy St Hilaire, 33600 Pessac, France
Institute Charles Gerhardt of Montpellier (ICGM), Place E. Bataillon, 34095 Montpellier, France
The French Alternative Energies and Atomic Energy Commission (CEA), Biosciences and Biotechnologies Institute (BIAM), 30200 Bagnols-sur-Cèze, France
NanoMedSyn, 15 Avenue Charles Flahault, 34090 Montpellier, France
Laboratoire Innovations technologiques pour la Détection et le Diagnostic (Li2D), Service de Pharmacologie et Immunoanalyse (SPI), CEA, INRA, 30207 Bagnols-sur-Cèze, France
Max Mousseron Biomolecule Institute of Montpellier (IBMM), 15 Avenue Charles Flahault, 34090 Montpellier, France
Author to whom correspondence should be addressed.
Biomimetics 2018, 3(3), 22;
Received: 29 June 2018 / Revised: 1 August 2018 / Accepted: 2 August 2018 / Published: 15 August 2018
(This article belongs to the Special Issue Selected Papers from NanoBio&Med 2017)
Careful analysis of any new nanomedicine device or disposal should be undertaken to comprehensively characterize the new product before application, so that any unintended side effect is minimized. Because of the increasing number of nanotechnology-based drugs, we can anticipate that regulatory authorities might adapt the approval process for nanomedicine products due to safety concerns, e.g., request a more rigorous testing of the potential toxicity of nanoparticles (NPs). Currently, the use of mesoporous silica nanoparticles (MSN) as drug delivery systems is challenged by a lack of data on the toxicological profile of coated or non-coated MSN. In this context, we have carried out an extensive study documenting the influence of different functionalized MSN on the cellular internalization and in vivo behaviour. In this article, a synthesis of these works is reviewed and the perspectives are drawn. The use of magnetic MSN (Fe3O4@MSN) allows an efficient separation of coated NPs from cell cultures with a simple magnet, leading to results regarding corona formation without experimental bias. Our interest is focused on the mechanism of interaction with model membranes, the adsorption of proteins in biological fluids, the quantification of uptake, and the effect of such NPs on the transcriptomic profile of hepatic cells that are known to be readily concerned by NPs’ uptake in vivo, especially in the case of an intravenous injection. View Full-Text
Keywords: nanoparticles; safety; mesoporous silica; protein corona; internalization; adverse outcome pathways nanoparticles; safety; mesoporous silica; protein corona; internalization; adverse outcome pathways
Show Figures

Graphical abstract

MDPI and ACS Style

Rascol, E.; Pisani, C.; Dorandeu, C.; Nyalosaso, J.L.; Charnay, C.; Daurat, M.; Da Silva, A.; Devoisselle, J.-M.; Gaillard, J.-C.; Armengaud, J.; Prat, O.; Maynadier, M.; Gary-Bobo, M.; Garcia, M.; Chopineau, J.; Guari, Y. Biosafety of Mesoporous Silica Nanoparticles. Biomimetics 2018, 3, 22.

AMA Style

Rascol E, Pisani C, Dorandeu C, Nyalosaso JL, Charnay C, Daurat M, Da Silva A, Devoisselle J-M, Gaillard J-C, Armengaud J, Prat O, Maynadier M, Gary-Bobo M, Garcia M, Chopineau J, Guari Y. Biosafety of Mesoporous Silica Nanoparticles. Biomimetics. 2018; 3(3):22.

Chicago/Turabian Style

Rascol, Estelle, Cédric Pisani, Christophe Dorandeu, Jeff L. Nyalosaso, Clarence Charnay, Morgane Daurat, Afitz Da Silva, Jean-Marie Devoisselle, Jean-Charles Gaillard, Jean Armengaud, Odette Prat, Marie Maynadier, Magali Gary-Bobo, Marcel Garcia, Joël Chopineau, and Yannick Guari. 2018. "Biosafety of Mesoporous Silica Nanoparticles" Biomimetics 3, no. 3: 22.

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

Back to TopTop