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Biomimetics 2018, 3(3), 19; https://doi.org/10.3390/biomimetics3030019

Alterations in Cellular Processes Involving Vesicular Trafficking and Implications in Drug Delivery

1
Institute for Bioscience and Biotechnology Research and Fischell Department of Bioengineering, University of Maryland, College Park, MD 20742, USA
2
Catalan Institution for Research and Advanced Studies (ICREA), 08010 Barcelona, Spain
3
Institute for Bioengineering of Catalonia (IBEC) of the Barcelona Institute of Science and Technology (BIST), 08028 Barcelona, Spain
Received: 16 June 2018 / Revised: 9 July 2018 / Accepted: 10 July 2018 / Published: 24 July 2018
(This article belongs to the Special Issue Selected Papers from NanoBio&Med 2017)
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Abstract

Endocytosis and vesicular trafficking are cellular processes that regulate numerous functions required to sustain life. From a translational perspective, they offer avenues to improve the access of therapeutic drugs across cellular barriers that separate body compartments and into diseased cells. However, the fact that many factors have the potential to alter these routes, impacting our ability to effectively exploit them, is often overlooked. Altered vesicular transport may arise from the molecular defects underlying the pathological syndrome which we aim to treat, the activity of the drugs being used, or side effects derived from the drug carriers employed. In addition, most cellular models currently available do not properly reflect key physiological parameters of the biological environment in the body, hindering translational progress. This article offers a critical overview of these topics, discussing current achievements, limitations and future perspectives on the use of vesicular transport for drug delivery applications. View Full-Text
Keywords: cellular vesicles; vesicle fusion; fission and intracellular trafficking; drug delivery systems and nanomedicines; transcytosis and endocytosis of drugs carriers; disease effects on vesicular trafficking; drug effects on vesicular trafficking; role of the biological environment cellular vesicles; vesicle fusion; fission and intracellular trafficking; drug delivery systems and nanomedicines; transcytosis and endocytosis of drugs carriers; disease effects on vesicular trafficking; drug effects on vesicular trafficking; role of the biological environment
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Muro, S. Alterations in Cellular Processes Involving Vesicular Trafficking and Implications in Drug Delivery. Biomimetics 2018, 3, 19.

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